Products at a Glance 2024

www.pelobiotech.com

www.pelobiotech.com designed 3D CoSeedis TM as a robust platform for mass-production of highly homogeneous and uniform organoids and spheroids which makes HTS/HCS applications. Available products sold together with single use or long-term licenses • 3D CoSeedis TM Chip200 (6 well format, 200 organoids per chip), Cat# C200 or C200-6 (6 chips) • 3D CoSeedis TM Chip880 (6 well format, 880 organoids per Chip), Cat# C880 • 3D CoSeedis TM Chip680 (24 well format, 680 organoids per chip), Cat# C680 or C680-6 or C680-12 (12 chips) • Accessories 3D CoSeedis TM Spatula , Spatula for matrix handling, sterile, • Spheroid Formation Media • Single Use License: Get easy and fast access to our assays for in-house tests • Long-Term License: Get easily access to the assays of your choice and have your planning certainty and support for as long as your project is running • Custom-Tailored: You decide what you need and we offer you the best possible license terms Available services - predicting drug functionality and efficacy: accurate, reliable and fast • 3D Cell Culture Services ­ from cell isolation to 3D organoid/spheroid model using the 3D CoSeedis TM technology. The 3-in-1 Plate & EZ-Seed-Plate APRICELL Biotechnology´s EZ-Seed is a culture insert (based on Agarose) for the production of tumor spheroids. The inserts are designed for a 12 well plate and can be used to produce 480 monosize spheroids per 12 well plate. The possible spheroid size is between 300-600 µm (Cat#: APL-EZ-700). ABLE® Biott® Bioreactors ABLE BIOTT 3D disposable 30 ml bioreactors are designed with delta-shaped impellers and a conical shaft which offers ideal spheroid formation conditions for IPS cells. The bioreactors needs the Bioreactor System Controller and Motor as well as the Bioreactor Magnetic Stir System Base (30 and 100 ml). • 30 ml Bioreactor flask capacity, 5- to 10-fold cell expansion is possible (up to 50 million cells per flask) • 200-300 μm spheroids • Material (high-density polycarbonate) is compatible with iPS cell cultivation • Vessel interior is surface treated for biocompatibility • Polypropylene screw cap contains 0.2 μm nylon membrane • Sterile • Pack of 6 bioreactors This system can be used for various purposes such as: 46

www.pelobiotech.com 1. Tissue Engineering Research: Benchtop fluid bioreactors are employed in tissue engineering studies to simulate physiological conditions for the cultivation of cells and tissues. These systems allow researchers to investigate cell behavior, tissue development, and the impact of different factors on tissue growth and functionality. 2. Regenerative Medicine: Fluid bioreactors are crucial for the development of regenerative medicine therapies. They provide controlled environments to support the growth and maturation of bio-engineered tissues, facilitating the creation of functional substitutes for damaged or diseased tissues. 3. Drug Testing and Screening: These bioreactors are utilized for drug testing and screening purposes. The 3D cell cultures in fluid bioreactors more accurately mimic in vivo conditions compared to traditional 2D cell cultures, allowing for better predictions of drug responses and toxicity. 4. Vascularization Studies: To create functional and viable tissues, vascularization is a critical factor. Fluid bioreactors enable researchers to study and optimize the vascularization process within bio-engineered tissues, improving the overall success of tissue transplantation. 5. Stem Cell Expansion: Benchtop fluid bioreactors are used for the expansion of stem cells, providing a controlled environment to support the proliferation and differentiation of stem cells into specific cell lineages required for tissue engineering applications. 6. Bioprocess Development: These bioreactors play a role in developing and optimizing bioprocesses for large-scale production of bio-engineered tissues. Understanding the requirements for scale-up and maintaining a consistent and controlled environment is crucial for successful tissue production. 7. Muscle and Skeletal Tissue Engineering: Researchers use fluid bioreactors to create bio-engineered muscle and skeletal tissues. The controlled fluid flow and nutrient supply in these systems contribute to the development of tissues with improved structural and functional properties. 8. Cartilage Regeneration: Benchtop fluid bioreactors are employed in the development of bio-engineered cartilage tissues. The controlled mechanical forces and nutrient supply within the bioreactor contribute to the formation of cartilage structures with desired properties. 9. Connective Tissue Engineering: The creation of connective tissues, such as tendons and ligaments, involves using fluid bioreactors to simulate the mechanical forces and biochemical cues needed for tissue maturation and functionality. EZSPHERE TM Multi-Well Plates and Dishes (AGC ® ) EZSPHERE multi-well plates and dishes (AGC ® ) are coated with a cell/protein repellent (SP polymer) and made from polystyrene plastic. Unique features are the micro-wells laser etched to the bottom of the plates or dishes. EZSPHERE is used to generate high numbers of spheroids. The spheroid size is limited by the dimensions of the wells. Available are dishes from 35 – 100 mm, 6 and 96 well plates. 47