Products at a Glance 2024

www.pelobiotech.com

www.pelobiotech.com Furthermore, the establishment of living biobanks comprising patient-derived xenografts, primary tumor tissue, normal tissue, sera, and cancer cell lines has facilitated the study of tumor characteristics and mechanisms of atherosclerosis. The expression of PDX-1, a key regulator of beta cell maturation and differentiation, has been investigated in pancreatic cancer, shedding light on its significance in the disease. Moreover, the potential of stem cells in the treatment of skeletal muscle injury and disease has been explored, highlighting the therapeutic implications of multipotent stem cells derived from adult bone marrow, fat, skin, periosteum, and muscle. These studies collectively demonstrate the wide-ranging applications of these cell types in advancing our understanding of various diseases and in the development of novel therapeutic strategies. Kidney We offer a range of fibroblasts, endothelial cells, epithelial cells, mesangial cells, and podocytes from various regions of the kidney, sourced from different species. Fibroblasts play a crucial role in renal fibrosis, and their origin in renal fibrosis has been a subject of controversy, highlighting the importance of understanding their role in kidney pathology. Endothelial cells have been studied for their involvement in angiogenesis and their response to various factors in the context of kidney diseases, providing insights into their role in kidney function and pathology. Epithelial cells have been investigated for their protective role against oxidative cell injury, shedding light on their significance in acute kidney injury and chronic kidney diseases. Mesangial cells have been shown to participate in immune function in the kidney and have been studied for their role in maintaining the structure and function of the glomerulus and in the pathogenesis of glomerular diseases. Podocytes have been studied for their involvement in renal fibrosis and their response to growth factors, providing insights into their role in kidney fibrosis and compensatory hypertrophy. The study of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney has provided valuable insights into the fate of these cells in the kidney, particularly following renal injury, contributing to our understanding of kidney regeneration and disease progression. Additionally, the expression of a novel mesangium-predominant gene, Megsin, in the renal tissues of various glomerular diseases has been investigated, shedding light on its potential role in the pathogenesis of kidney diseases. Moreover, the use of laser ablation of the zebrafish pronephros to study renal epithelial regeneration has provided a novel tool for the study of epithelial injury in zebrafish, offering insights into kidney regeneration and repair. These studies collectively contribute to a comprehensive understanding of kidney biology and pathology, providing a basis for the development of novel therapeutic strategies for kidney diseases. Intestine Smooth muscle cells have been investigated for their involvement in intestinal motility, peristalsis, and the pathogenesis of intestinal fibrosis. Studies have shown that smooth muscle cells play a crucial role in the regulation of intestinal motility and peristalsis, and their phenotypic plasticity has been implicated in mechanical obstruction of the small intestine. Smooth muscle cells have been used in tissue engineering for intestinal reconstruction, exhibiting spontaneous rhythmic contraction in vitro and showing potential for functional smooth muscle bioengineering. Fibroblasts have been studied for their involvement in intestinal fibrosis, inflammation, and the regulation of intestinal epithelial cells. Studies have shown that fibroblasts play a role in the pathogenesis of intestinal strictures in Crohn's disease and have been implicated in the secretion of inflammatory mediators from LPS-induced rat intestinal microvascular endothelial cells. Additionally, fibroblasts have been shown to modulate colonocytes in co-culture and contribute to the development of intestinal fibrosis. Endothelial cells have been extensively studied for their involvement in intestinal microvascular development, angiogenesis, and the regulation of intestinal fibrosis. Studies have shown that endothelial cells express Toll-like receptor 5 and are involved in the secretion of inflammatory mediators from LPS-induced rat intestinal microvascular endothelial cells. 16

www.pelobiotech.com Additionally, endothelial cells have been implicated in the development of intestinal fibrosis and have been shown to contribute to the pathogenesis of necrotizing enterocolitis. Epithelial cells have been investigated for their involvement in intestinal inflammation, barrier function, and the response to radiation-induced injury. Studies have shown that epithelial cells are involved in radiation-induced intestinal injury, with the epithelial cells being the most important target of radiation damage, which may subsequently induce apoptosis in endothelial cells. Scan the QR code to see our full cell list. Urethra We provide primarily epithelial cells from the urethra, and the RNA of these cells as well. The primarily epithelial cells from the urethra have been studied for their role in the development, function, and regeneration of the urethra. These cells have been shown to express androgen receptors, and their differentiation has been observed in the urothelium of the prostatic urethra and prostatic luminal epithelial cells. Single-cell RNA sequencing has been used to obtain a complete transcriptomic profile of all epithelial cells in the mouse prostate and urethra to identify cellular subtypes. The expression of cytokeratin 7, uroplakin, and FoxA1 has been observed in the urethral plate and developing urethra of the penile glans, indicating the presence of proteins of epithelial cells of endodermal origin. The urethral luminal epithelia have been identified as castration-insensitive cells of the proximal prostate, and they have been shown to undergo a prostate luminal to club cell transition in benign prostatic hyperplasia. Additionally, the urethral epithelial cells have been used in the fabrication of tissue-engineered bionic urethras using cell sheet technology for fullthickness urethral reconstruction. These studies collectively demonstrate the diverse applications of primarily epithelial cells from the urethra in understanding urethral development, function, and regeneration. Stomach We extract epithelial cells, smooth muscle cells, and primary stomach cells from the stomach, sourcing them from various species. Epithelial cells from the stomach have been investigated for their role in the development and function of the stomach. Studies have shown that the completeness of the stomach development is marked by the appearance of non-specific esterase activity in the stomach epithelial cells. Additionally, the adherence of lactic acid bacteria to the columnar epithelial cells of the stomach has been studied, providing insights into the microbial colonization of the stomach. Smooth muscle cells from the stomach have been studied for their involvement in gastric motility and the pathogenesis of stomach diseases. These cells play a crucial role in the regulation of gastric motility and peristalsis, contributing to the digestive function of the stomach. Umbilical cord We isolate a range of cell types, including human umbilical vein endothelial cells, various shRNA-stable transfected HUVECs, HUVECs with GFP tags in the mitochondria and plasma membrane, conditionally immortalized umbilical cord MSCs, HUVECs from arteries and veins, and whole cell RNAs. The uses of human umbilical vein endothelial cells (HUVECs) are diverse and significant in various research areas. HUVECs have been utilized in studying cytoprotective pathways, modeling atherosclerosis, investigating protective effects against injury, analyzing angiogenesis and lymphangiogenesis, and exploring autophagy induction. HUVECs have been employed in the study of lactateinduced pathways in endothelial cells, as well as in investigating the effects of activated protein C on endoplasmic reticulum stress and apoptosis. 17