Products at a Glance 2024

www.pelobiotech.com Dyes

www.pelobiotech.com Dyes You can find a wide range of dyes for microscopy that can be used to stain various cellular organelles, proteins, membranes, and nucleotides. There are live cell dyes available that allow for organelle visualization with organelleselective stains (e.g. ER, mitochondria, Golgi) or function assays like, e.g. live cell tracking, labeling, cell proliferation, or live dead assays. You may find a brief overview of our product range in the table below: Product NucleoSeeing CytoSeeing ERseeing LipiDye FAOBlue Thermoprobes Ap3 PolyamineRED Application Live cell imaging, cell cycle studies, DNA damage assessment, environmental stress studies, drug screening, cell viability assays, cell sorting and isolation, cancer research, intracellular pH monitoring Our microscopy dyes provide live cell visualization without compromising cell viability. They allow tracking of cell division and migration, co-staining with other probes, and are suitable for FACS or flow cytometry analysis. A permanent endoplasmic reticulum (ER) staining dye is a versatile tool for cellular research and diagnostics. It aids in studying ER morphology, monitoring cellular health, assessing ERrelated diseases, evaluating drug effects, diagnosing conditions, and enabling precise cell sorting. Our specialized lipid detection dye is essential for imaging live and fixed cells, particularly for staining tiny lipid droplets smaller than 1 micrometer, a task often challenging for conventional dyes like Nile Red. This unique capability is invaluable in lipid metabolism and cell biology research, enabling detailed insights into cellular processes, lipid dynamics, and lipid-related disorders like obesity and diabetes. Our fatty acid oxidation detection dye simplifies live cell imaging and offers insight into singlecell metabolic activity. Its applications extend to NASH research, allowing for the assessment of liver cell lipid metabolism, as well as broader metabolic studies for treatments and disease states. This dye is ideal for real-time, dynamic metabolic observations and interventions in metabolic disorders. Our live polymeric thermometer dye provides real-time intracellular temperature insights for living cells, making it a valuable tool in fields like cancer research, neuroscience, and drug development. It allows researchers to study cellular responses to treatments and conditions, uncover temperature regulation mechanisms, and understand how temperature fluctuations impact cellular processes, all in a non-invasive and continuous manner. Our SHG detection dye is essential for enhancing true SHG signal detection and enabling multimodal imaging. It has applications in neuroscience for visualizing neural structures, in tissue engineering for studying extracellular matrix components and cell interactions, and in material science for analyzing material properties and molecular arrangements. This dye plays a crucial role in advancing research in these diverse fields. PolyamineRED is a powerful tool for the non-invasive, semi-quantitative detection of intracellular polyamines without the need for pre-treatment or cell lysis. This versatile dye finds applications in diverse fields, including cancer research, neurobiology, and drug development. It enables the study of polyamine levels and distribution within live cells, offering insights into cancer progression, neuronal function, and the evaluation of potential drug candidates targeting polyamine-related pathways. 64

www.pelobiotech.com Proteins Proteins, essential building blocks of life, are pivotal in diverse scientific applications. Their structural intricacies, unveiled through techniques like X-ray crystallography, inform drug design and targeted therapies. Serving as enzymatic catalysts, proteins drive biochemical reactions crucial for biotechnology, medicine, and environmental science. In cell signaling, proteins regulate physiological responses and are targets for therapeutic interventions, especially in diseases like cancer. Biotechnological advancements leverage proteins for synthesizing therapeutic agents and engineering novel functions in synthetic biology. Additionally, proteins are indispensable in diagnostics, with biomarkers aiding disease detection and monitoring. In essence, proteins are the linchpin of scientific progress, contributing to our understanding of life and propelling innovations across various disciplines. Recombinant Proteins Our extensive offering includes a diverse range of recombinant proteins targeting CD73, GPC3, Siglec-15, FGL1, and more. Available in formats like Fc-fusion, 6His-tag, and Fc-tag, these proteins are sourced from various entities—human, mice, rat, rhesus, rabbit, and even viruses like SARS-CoV-2. Biotinylated versions add flexibility to your research. Essential proteins like immunoglobulins and VEGFR further empower investigations across scientific domains. Human Proteins Recombinant human proteins play vital roles in medicine and biotechnology. Insulin manages diabetes, PDGFs aid wound healing, and growth factors like SCF, bFGF, and EGF contribute to cell proliferation and tissue regeneration. TGF-beta 1 regulates growth and differentiation, ensuring high-quality standards through cGMP. Proteins like GM-CSF stimulate white blood cell production, and cGMP-produced EPO is vital for treating anemia. Enzymes Anti-lysozyme, anti-cystatin C, and anti-gelsolin serve as valuable tools in research and diagnostics, detecting and quantifying specific proteins. Amylase detection kits (amY-Kit) assess amylase activity for insights into pancreatic and salivary gland function. The animal-free nature of these proteins ensures ethical production methods, setting them apart from cGMP-produced counterparts. Growth Factors Animal-free growth factors play pivotal roles in cell growth, proliferation, and differentiation. PDGFs aid wound healing, FLT-3L stimulates immune cell production, and M-CSF regulates macrophage development. Oncostatin M and TGF beta 3 find applications in inflammation, tissue regeneration, and embryonic development. VEGFs are key players in angiogenesis, RANK Ligand is essential for bone remodeling, and beta NGF is involved in the nervous system. Animal-free versions ensure ethical and controlled applications. Chemokines Among the diverse offerings, chemokines play a crucial role in immune responses and inflammation. Chemokines guide the movement of immune cells to specific sites in the body. Examples include CCL2 (Monocyte Chemoattractant Protein-1) and CXCL8 (Interleukin-8), which attract monocytes and neutrophils, respectively. These chemokines are valuable tools in research, particularly in studying diseases involving immune cell recruitment. Their application extends to diagnostics, aiding in the detection and quantification of specific proteins. The ethical and controlled production of these chemokines distinguishes them from cGMP-produced counterparts. Cytokines Cytokines have diverse applications in immunotherapy, cancer treatment, and research. ILs modulate immune responses, with IL-2 used in cancer immunotherapy. TNF-alpha is employed in cancer treatment and autoimmune 65