Products at a Glance 2024

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www.pelobiotech.com Assays Angiogenesis Assays Cell based Assays Cell Purity Kits Chimerism Assays Metallo Quantification Assays Metastasis Assays TR-FRET Kits Angiogenesis Assays Angiogenesis assays are crucial tools for studying the formation of new blood vessels from existing ones. They have broad applications in biomedical research, helping scientists investigate angiogenesis mechanisms, test potential therapies, and understand its role in diseases like cancer, cardiovascular conditions, and wound healing. These assays measure endothelial cell activities, aiding in the development of treatments targeting angiogenesis-related disorders. These products are a series of in vitro angiogenesis tracing kits designed for specific microvascular regions in the human body, including the brain, glomerular, lymphatic, pancreatic, and retinal areas. They provide researchers with tools to study and trace angiogenesis processes in these distinct microvascular environments. 70

www.pelobiotech.com Cell-based Assays (ECM Assays) Cell biology assays are pivotal in the field of life sciences, enabling researchers to investigate and understand various cellular processes. Among the essential tools are the Cyto-X Solution, available in both full kits and sample sizes, which provide a colorimetric method for precise cell counting. For researchers interested in the extracellular matrix (ECM) and its influence on cell behavior, the MicroMatrix 36 and MicroMatrix 36-4 Pack are ideal for testing the most suitable ECM for specific cell types. The screenMatrix in a 96-well format facilitates high-throughput screening, making it a valuable tool for cell biology studies. These assays collectively contribute to our understanding of cellular functions and the optimization of cell culture conditions. Cell Purity Kits Accumol's MTBN Purity Assessment Kit is a versatile tool for detecting Monocyte, T-Cell, B-Cell, and Neutrophil mRNA in genomic DNA samples isolated from sorted cells. This kit is specifically designed to quantify lineage-specific RNAs that are co-purified during standard DNA isolation procedures. After reverse transcription and PCR amplification, the resulting products can be analyzed on a sequencer or traditional gels. This test is not influenced by the presence of beads or antibodies on sorted cells' surfaces and can be applied regardless of the sorting method used. Furthermore, as it assesses purity at the nucleic acid level, it allows for delayed analysis, even months after cell sorting. Chimerism Assays Checking chimerism, the presence of two or more genetically distinct cell populations within an individual, is crucial for a variety of applications in the field of medicine and research. The provided Non-B Genomic Detection Kits and Non-T Genomic Detection Kits, as well as the qPCR Non-Myeloid Genomic Detection Kit, offer powerful tools for this purpose. Chimerism testing plays a vital role in clinical contexts, such as post-transplant monitoring, where assessing the proportion of donor and recipient cells is essential to evaluate the success of organ or bone marrow transplants. It is also instrumental in identifying and tracking the presence of foreign cells in cases of graft-versus-host disease and determining the effectiveness of therapeutic interventions. In forensic science, chimerism testing is valuable for solving complex cases by distinguishing between the DNA profiles of individuals. In research, chimerism analysis helps scientists understand developmental processes, genetic mosaicism, and the dynamics of cell populations within organisms. These detection kits are indispensable in these applications, providing accurate and reliable methods to assess chimerism, ultimately contributing to improved patient care, the advancement of forensic investigations, and a deeper understanding of biological mechanisms. Metallo-quantification Assays Metallo quantification assays, such as the Copper, Iron, Magnesium, and Zinc Assay kits provided, are essential tools in analytical chemistry and various scientific disciplines. These kits offer precise methods for quantifying the concentration of specific metal ions in various samples, employing different detection techniques like the 3,5-DiBr-PAESA, Ferrozine, Nitroso- PSAP, Xylidyl Blue-I, and 5-Br-PAPS methods. In the field of clinical and biomedical research, metallo quantification is important for understanding the role of metal ions in biological processes, such as iron in hemoglobin or copper in enzymes. Monitoring metal ion concentrations is also vital for diagnosing and managing various diseases, including iron-deficiency anemia and Wilson's disease. Metastasis Assays Metastasis is a critical process in cancer biology, where cancer cells spread from the primary tumor to other parts of the body, often leading to advanced disease and poor patient outcomes. The IN SITE Metastasis Hydrogel Kit and Metastasis Surface Coating Kit are instrumental tools in studying and understanding this complex phenomenon. By recreating a 71