Products at a Glance 2024

www.pelobiotech.com 3D

www.pelobiotech.com 3D Scaffold-based Organotypic Scaffolds - only available on demand Our partner Xylyx Bio has developed TissueSpec ® ECM Scaffolds based on ECM proteins isolated from different porcine organs. Human organotypic scaffolds are available only on demand. Pic: The TissueSpec ® Matrix Scaffolds retain the natural 3D structure, biomechanics and topography of native porcine tissues. The scaffolds contain tissuespecific factors and architecture. What are the features of TissueSpec ® Matrix Scaffold? • 3D acellular native matrix construct • Derived from normal porcine tissue • Preserves native tissue architecture • Can be used in-vitro as well in-vivo • Compatible with fluorescence & light microscopy • Customized in size • Ready-to-use What type of TissueSpec ® Matrix Scaffolds are available on demand? • Bone • Cartilage • Heart • Intestine • Kidney • Liver • Lung • Skin 48

www.pelobiotech.com SEEDEZ TM What is SEEDEZ TM ? Our partner Lena Biosciences offers a robust 3D cell culture system for routine, predictive testing in vitro. SEEDEZ TM is a three-dimensional cell culture scaffold made of randomly oriented, inert glass microfibers. The diameter of microfibers is carefully optimized for long-term cell growth and repeat-dose drug testing. The microfibers are arranged in such a way that creates tiny pores for nutrients, gases, and metabolites to pass through the scaffold allowing normal cell functions. With a simple workflow and consistent composition, SEEDEZ TM can be used with all cell types. SEEDEZ TM enables the cells to utilize their cadherin (cell-to-cell connections) and integrin (cell-to-ECM) receptors which are vital for biomimetic functions of the engineered tissue. Unlike soft hydrogel-based scaffolds SEEDEZ TM does not peel off the culture dish or get drawn into the pipette tip. When compared to less porous and more rigid scaffolds, cells permeate SEEDEZ TM readily. How it works! At a glance: • Supports most cell types • Supports most ECMs • Consistent 3D cell distribution • Consistent cultures • Long-term culture (2 months+) • In-well assaying • Assay multiplexing • Fluorescence imaging • Easy to transfer from dish-to-dish • Cells can be recovered • Custom diameters upon request Applications: • Culture complex 3D cell culture and co-culture models long-term; • Small molecule drug testing (drug metabolism, toxicity etc.); • Testing on-target efficacy/ off-target toxicity of antibody-drugconjugates & multi-specific antibodies. SEEDEZ TM So easy to use! Just unwrap product, add cell suspension in appropriate medium at optimized seeding density and place in incubator to culture cells in 3D Is SEEDEZ TM compatible with other assays? 3D tissues grown in SEEDEZ TM can be studied using a variety of standard molecular and cellular techniques. Cells can be harvested by using passaging solutions (e.g. trypsin or Accutase. DNA/RNA and proteins can be isolated direct out of the scaffolds. 49