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Neurobiologie van eetstoornissen; over muizen en ... - Altrecht

Neurobiologie van eetstoornissen; over muizen en ... - Altrecht

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α-MSH<br />

POMC ↑<br />

-<br />

Food intake<br />

MC4R<br />

Leptin ↑ Leptin ↓<br />

Weight gain Weight loss<br />

Vet<br />

+<br />

AgRP ↑<br />

Melanocortine signalering<br />

MC4r<br />

MC4r<br />

α-MSH<br />

Adan and Kas, Tr<strong>en</strong>ds in Pharmcol. Sci., 2003<br />

The yellow mouse obesity syndrome<br />

Ubiquitously expression of Agouti<br />

Melanocortin-3 and 4 receptor<strong>en</strong> in het brein<br />

6

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