Esquistossomose mansoni humana: Análise do papel da ... - Unifenas

ABSTRACT
group. Addition of recombinant IL-10 to the cultures readily decreased the
percentages of all receptors in most of the individuals.
The effect of IL-10 on the HS group was evaluated by the expression of all
molecules investigated. The results did not show any difference on the expression
of receptors, neither in the presence nor in the absence of anti-IL-10 monoclonal
antibodies after the granuloma formation. On the other hand, the L-selectin and HLA-
DR molecules were highly expressed in the HS group when compared to the INT
group. The results presented in this study suggests that the high expression of these
molecules may be correlated with the severity of the infection. Furthermore, the
modulation of CD28 on the CD8 + cells in this group did not appear to be due to IL-
10, since the addition of anti-IL-10 blocking antibodies to the in vitro granuloma
cultures did not alter the percentage of expression of this molecule.
Finally, the results generated in this thesis allowed the evaluation of cells
populations expressing acessory molecules after the in vitro granuloma formation
during the chronic intestinal phase. Together, these data strengthen the idea of IL-10
being a key player in determining the control of the morbidity in Schistosomiasis.
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