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medicină veterinară - Ion Ionescu de la Brad

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Lucrări Științifice – vol. 51 seria Medicină Veterinară<br />

CONCLUSIONS<br />

1. The performance of a therapeutical protocol, which meant the gradual <strong>de</strong>scending<br />

administration of ketoprofen, had as purpose the diminishing and even the avoidance, as much<br />

as possible, of the si<strong>de</strong> effects occurrence (gastrointestinal, renal), which are frequently<br />

encountered during ketoprofen administrations that <strong>la</strong>st more than 5 – 7 days, with a dosage of<br />

2 mg/kg/day.<br />

2. No significant si<strong>de</strong> effects were noted after the gradual <strong>de</strong>creasing dose administration of<br />

ketoprofen, such as gastrointestinal or renal modifications.<br />

3. The efficiency of ketoprofen was noticed even from the 3 rd day of treatment, and the recovery<br />

happened gradually, the normal functioning being noted from the 11 th day of therapy.<br />

4. The hematological and biochemical parameters also returned to normal by the end of the<br />

treatment, in all the studied dogs.<br />

5. It was also observed that the medical substance was well tolerated by all dogs and had a positive<br />

effect on pain reduction and acute inf<strong>la</strong>mmation.<br />

BIBLIOGRAPHY<br />

1. Boothe DM., 1995 - The analgesic-antipyretic-anti-inf<strong>la</strong>mmatory drugs. In: Adams RH, editor. Veterinary<br />

pharmacology and therapeutics. 7th ed. Ames, IA: Iowa University Press;p. 432–49.<br />

2. Garcia ML, Tost D, Vi<strong>la</strong>geliu J, et al., 1998 - Bioavai<strong>la</strong>bility of S(+)- ketoprofen after oral administration of<br />

different mixtures of ketoprofen enantiomers to dogs. J Clin Pharmacol Dec; 38(12 Suppl): 22S–26S.<br />

3. Grisneaux E, Pibarot P, Dupuis J, et al. 1999 - Comparison of ketoprofen and carprofen administered prior to<br />

orthopedic surgery for control of postoperative pain in dogs. J Am Vet Med Assoc Oct 15; 215(8): 1105–10.<br />

4. Katheeri NA, Wasfi IA, Lambert M, et al., 2000 - Pharmacokinetics of ketoprofen enantiomers after<br />

intravenous administration of racemate in camels: effect of gen<strong>de</strong>r. J Vet Pharmacol Ther; 23(3): 137–43.<br />

5. Lemke KA, Runyon CL, Horney BS. 2002 - Effects of preoperative administration of ketoprofen on whole<br />

blood p<strong>la</strong>telet aggregation, buccal mucosal bleeding time, and hematologic indices in dogs un<strong>de</strong>rgoing elective<br />

ovariohysterectomy. J Am Vet Med Assoc Jun 15; 220(12): 1818–22.<br />

6. Sams R, Gerken DF, Ashcraft SM. 1995 - Pharmacokinetics of ketoprofen after multiple intravenous doses to<br />

mares. J Vet Pharmacol Ther; 18: 108–16.<br />

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