Hele bladet i pdf-format - Gamma - Niels Bohr Institutet
Hele bladet i pdf-format - Gamma - Niels Bohr Institutet
Hele bladet i pdf-format - Gamma - Niels Bohr Institutet
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En model for rygradens dannelse <strong>Gamma</strong> 150<br />
concentration [nM]<br />
3<br />
2.5<br />
2<br />
1.5<br />
1<br />
0.5<br />
0<br />
150<br />
100<br />
50<br />
Nicd<br />
β−cat<br />
0<br />
0 100 200 300 400 500 600<br />
time [min]<br />
Axin2<br />
Lfng/Hes<br />
Figur 8: Tidsserie for det samlede Wnt-Notch system. Det øverste panel angiver oscillationerne<br />
af transkriptionsfaktorerne i de systemer, og nederste panel angiver de protein<br />
oscillationer det udmønter sig i, i de to systemer.<br />
Litteratur<br />
[1] K.J.Dale and O.Porquie: A clock-work somite. Bioessays, 22(1):72-83,2000<br />
[2] A. Aulehla and B.G. Herrmann. Segmentation in vertebrates: Clock and gradient<br />
finally joined. Genes Dev, 18(17):2060-7, 2004<br />
[3] M.L.Dequeant, E.Glynn, K.Gaudenz, M.Wahl, J.Chen, A.Mushegian and<br />
O.Pourquie. A complex oscillating network of signaling genes underlies the mouse<br />
segmentation clock. Science, 314(5805):1595-8, 2006<br />
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