Wien, 28 - Repository of the LBI-HTA - Ludwig Boltzmann Gesellschaft

DatenextraktionAuthor, year, referencenumberBaek (2010) [16] Deandra (2008) [24] Spieza (2009) [3]Nodule volume(in ml; recorded by US)enrolment:observation : O/ 6.9 ±4.o (range 2.7-16.1)RFA: O/ 7.5 ±4.9 (range 1.7-20)after 6 months:observation : O/ 7.1 ±3.8 (range 3.1-16.2); p = 0.46 8RFA: O/ 1.3 ±0.8 (range 0.2-2,6); p = 0.001 9enrolment: O/ 27.4 ± 21.5after 1 month: O/ 19.2 ± 16; p < 0.0001after 3 months: O/ 15.9 ± 14.1; p < 0.0001after 6 months: O/ 14.6 ± 12.6; p < 0.0001Thyroid function n/a enrolment: hyperthyroidism: 23 (69.7%)after 3 months: hyperthyroidism: 0 (0%); p=n/a,partial remission: 16 (48.5%); p=n/aSafetyenrolment: O/ 24.5 ± 2.1after 1 month: O/ 13.8 ± 1.7; p < 0.001after 3 months: O/ 11.1 ± 1.6; p < 0.001after 6 months: O/ 8.9 ± 1.4; p < 0.001after 12 months: O/ 7.5 ± 1.2; p < 0.001enrolment: pretoxic TN: 15 (16%)toxic TN: 13 (13.8%)after 24 months: pretoxic TN: 0 (0%); p=n/atoxic TN: 6 (6.4%); p=n/aComplicationsno major complications, only mild pain and feeling ofheat in neck- no major complications, only mild pain and feeling ofheat in neck during RFA.- 3 (9.7%) patients required betamethasone to controledema after RFA.- few patients reported slight cervical pain 24 h after RFA.Procedure-related mortality 0 (= 0%) 0 (= 0%) 0 (= 0%)M/F: male/female; n/a: not available; TNs: thyroid nodules; RF: radiofrequency; RFA: radiofrequency ablation; US: ultrasound- 13 (15.7%) patients had slight transient cervical pain24 h after RFA.- 5 (6%) patients had fever up to 38°C 24-36 h afterRFA.8 Refers to nodule volume of the observation group at 6 months follow-up compared to enrolment9 Refers to nodule volume of the RFA group at 6 months follow-up compared to enrolmentLBI-HTA | 2012 23