Wien, 28 - Repository of the LBI-HTA - Ludwig Boltzmann Gesellschaft

Radiofrequenzablation bei benignen und malignen Vera¨nderungen endokriner OrganeTabelle 5-3: Evidence profile: efficacy and safety of radiofrequency ablation for benign (aldosteron-producing) adenomas of the adrenal glandNo of studies/patientsDesign Limitations Consistency ofresultsDirectness Effect size* low incidence, lack of precise data, sparse data, strong or very strong association, high risk of publication bias, dose-efficacy gradient, residual confounding plausibleOther modifyingfactors*Quality ofevidenceEfficacyno evidenceSafetyOutcome: complications (pneumothorax, hematomas)1/24 case series serious limitations only 1 trial direct small pneumothorax (self-limiting): 4.2% (1 of 24 patients)lack of precise data, very lowretroperitoneal hematomas (resolved spontaneously): 12.5 % (3 of 24 patients) sparse dataOutcome: procedure-related mortality1/24 case series serious limitations only 1 trial direct 0 % sparse data very lowTabelle 5-4: Evidence profile: efficacy and safety of radiofrequency ablation for the treatment of metastases of the adrenal glandDesign Limitations Consistencyof resultsNo of studies/patientsDirectnessEffect sizeEfficacyOutcome: Survivalno evidenceOutcome: RecurrenceOther modifyingfactors*1/6 case series serious limitations only 1 trial direct 16.7% (1 of 6 patients) lack of precise data,sparse dataOutcome: Quality of lifeno evidenceSafetyOutcome: complications (pain and hematomas)1/6 case series serious limitations only 1 trial direct pain: 16.7% (1 of 6 patients)hypertension (post-RFA): 16.7% (1 of 6 patients)Outcome: procedure-related mortalityno evidencelack of precise data,sparse dataQuality ofevidencevery lowvery low* low incidence, lack of precise data, sparse data, strong or very strong association, high risk of publication bias, dose-efficacy gradient, residual confounding plausible34 LBI-HTA | 2012