Wien, 28 - Repository of the LBI-HTA - Ludwig Boltzmann Gesellschaft
Wien, 28 - Repository of the LBI-HTA - Ludwig Boltzmann Gesellschaft
Wien, 28 - Repository of the LBI-HTA - Ludwig Boltzmann Gesellschaft
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Qualita¨t der EvidenzTabelle 5-2: Evidence pr<strong>of</strong>ile: efficacy and safety <strong>of</strong> radi<strong>of</strong>requency ablation for thyroid cancerNo <strong>of</strong> studies/patientsDesign Limitations Consistency <strong>of</strong>resultsDirectness Effect size* low incidence, lack <strong>of</strong> precise data, sparse data, strong or very strong association, high risk <strong>of</strong> publication bias, dose-efficacy gradient, residual confounding plausibleEfficacyOutcome: SurvivalO<strong>the</strong>r modifyingfactors*1/11 case series serious limitations only 1 trial direct 91% at 1 month (10 <strong>of</strong> 11 patients) sparse data very lowOutcome: Recurrenceno evidenceOutcome: symptoms (discomfort/dysphagia)1/11 case series serious limitations only 1 trial direct enrolment: 27.2% discomfort; 18.1% dysphagiaafter 1-5 months: 18.1% (-9.1%) discomfort; 18.1 % (-0%) dysphagia; p=n/aSafetyOutcome: complications (skin burn, neck swelling and discomfort)1/11 case series serious limitations only 1 trial direct skin burn: 9.1% (1 <strong>of</strong> 11 patients)neck swelling and regional discomfort: 100% (11 <strong>of</strong> 11 patients)Outcome: procedure-related mortalitysparse datasparse data1/11 case series serious limitations only 1 trial direct 0% sparse data very lowQuality <strong>of</strong>evidencevery lowvery low<strong>LBI</strong>-<strong>HTA</strong> | 2012 33
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