2012 - Europe Direct Iasi

EUROINVENT 2012
natural antineoplastic product of veterinary use. Containing
agroclavine as bioactive agent (in naturally occuring form), it
had proved antitumoral action both in vitro (on HeLa tumoral
cells) and in vivo (on animals bearing either spontaneous cancer
or experimentally induced tumors). Its pharmacodynamic
effectiveness has been registered in small doses (50 μg
agroclavine/kg of body weight), which have also a low toxicity.
The proposed biotechnology includes: fermentation of Claviceps
purpurea fungus on proper nutritive medium and in physical
conditions which stimulates the clavinic alkaloids biosynthesis
and fungal biomass development in short time (7 days);
extraction from the liofilized mycelium; purifications by solvents
and resuspension of dry residuum in DMSO at a final
concentration of 250 μg bioactive product/ml.
Concomitantly with the significant antineoplastic effect induced
by intraperitonealy, intravenously or locally administrations of
the product to the animals with tumors, the new bioactive
product can be included in the group 1 of the hematological
toxicity (according with the classification of the World Health
Organization: 0-4 degree). The new experimental
oncochemotherapy has a good biocompatibility with life of the
tested organisms, a very good tolerability and can be used in
lower doses than those of some known anticancer drugs.
The new product is obtained by a non - polluted biotechnology,
is cheap and easy to be performed at industrial level and has a
high pharmacological value (enrichment of the „arsenal” of
Romanian compounds with oncochemotherapeutic properties,
from natural sources).
4.18.
Title HAM FOR TONING
Authors Marius NECULAES, Marin CHIRAZI, Andrei Victor SANDU
Alexandru Ioan Cuza University Iasi, Faculty of sports and
Institution
Physical Education
Patent no. Pending
The “Ham for toning” is meant for people of all ages with
deviations of the dorsal spine in sagittal plane, in order to correct
these deficiencies (kyphotic postures and kyphosis).
The orthosis is made of an elastic fabric for the front side of the
torso and of a non-elastic textile fabric for the back side, with an
Description
additional rigid paravertebral piece in order to create the
functional discomfort (pain) at that level. The elastic fabric on
the front side will bring the shoulders forwards, pulling and
compressing at the same time the paravertebral piece, thus
inducing pain at the level of the back. As a reflex mechanism to
reduce the pain, the patient will voluntarily contract the muscles
Class 4
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