FORENSIC TOXICOLOGY - Bio Medical Forensics

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Ropero-Miller, Jeri D. PhD*, RTI International, 3040 Cornwallis Road, PO Box 12194, Building 3, Room 116, Research Triangle Park, NC 27709; Peter R. Stout, PhD, Center for Forensic Sciences, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709; Katherine N. Moore, BS, Virginia Commonwealth University, Richmond, 611 West Cary Street, #209, Richmond, VA 23220; Robert Steiner, BS, Virginia Division of Forensic Sciences, 700 North 5th Street, Richmond, VA 23219; and John M. Mitchell, PhD, and Michael R. Baylor, PhD, Center for Forensic Sciences, RTI International, 3040 Cornwallis Road, Building 3, Research Triangle Park, NC 27709-2194 Ropero-Miller, Jeri D. PhD, RTI International, 3040 Cornwallis Road, PO Box 12194, Building 3, Room 116, Research Triangle Park, NC 27709; Peter R. Stout, PhD*, Kelly Shipkowski, BS, and John M. Mitchell, PhD, RTI International, Center for Forensic Sciences, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194; Michael R. Baylor, PhD, Center for Forensic Sciences, RTI International, 3040 Cornwallis Road, Building 3, Research Triangle Park, NC 27709- 2194; and Stacy Doorn, MS, and Owen Crankshaw, PhD, RTI International, 3040 Cornwallis Road, Johnson Building 105, Research Triangle Park, NC 27709 Ross, Karen F. MD* and Elizabeth H. Evans, BA, Jefferson Parish Forensic Center, 2018 8th Street, Harvey, LA 70058 Rossi, Riccardo MD*, Institute of Forensic Medicine, Catholic University, Largo Francesco Vito 1, Rome, ITALY; Antonio Oliva, MD, PhD, Institute of Forensic Medicine, Catholic University, School of Medicine, Ro, Largo Francesco Vito 1, Rome, ITALY; Fabio De Giorgio, MD, PhD, Institute of Legal Medicine, Rome, 00168, ITALY; Massimo Lancia, MD, and Cristina Gambelunghe, MD, Institute of Forensic Medicine, University of Perugia, Perugia, ITALY; and Nadia Fucci, PhD, Forensic Toxicology Laboratories, Catholic University, Rome, Italy, largo f. vito 1, Rome, ITALY Rubino, Allison M. MS*, 23 Woodland Avenue, Farmingdale, NY 11735; and Timothy M. Palmbach, JD, University of New Haven, Department of Forensic Science, 300 Boston Post Road, West Haven, CT 06516 Index 103 Development of a Web Accessible Cheminformatic Mass Spectral Database for Shared Utilization by Forensic Laboratories Analysis of Cocaine Analytes in Human Hair: Ultrastructural Evaluation of Human Hair by Microscopy for the Determination of Morphological Differences Following Surface Contamination and Laboratory Decontamination Deaths Due to the Acute Effects of Drugs Investigated in Jefferson Parish Louisiana Identification of GHB and Morphine in Hair in a Case of Drug Facilitated Sexual Assault Stability and Reproducibility Studies for Carbohydrate Deficient Transferrin Analysis Using Capillary Electrophoresis 15 20 230 37 8
Ruiz, Kazandra BS*, and Luz A. Silva Torres, BS, Puerto Rico Institute of Forensic Sciences, PO Box 11878, San Juan, Puerto Rico 00922- 1878; and Carlos F. Chavez- Arias, MD, Puerto Rico Institute of Forensic Sciences, PO BOX 11878, Caparra Heights Station, San Juan, Puerto Rico 00922-1878; Osca Peralta Narvaez, BS, Puerto Rico, Institute of Forensic Sciences, PO Box 11878, San Juan, Puerto Rico 00922-1878; Flor Mattos De Jesus, BS, Institute of Foresic Science, Calle Maga Esq. Casia, #9 Urb. Reparto Metropolitano, San Juan, Puerto Rico 00922; and Joseph Bloom-Oquendo and Jose Rodriguez- Orengo, PhD, Puerto Rico Institute of Forensic Sciences, PO BOX 11878, San Juan, Puerto Rico 00922-1878 Saady, Joseph J. PhD*, Virginia Department of Forensic Science, 700 North 5th Street, Richmond, VA 23219; and Amy Herin, MS, Virginia Commonwealth University, Department of Biostatistics, Richmond, VA 23219 Saady, Joseph J. PhD*,and Terri H. Woods, BS, Virginia Department of Forensic Science, 700 North 5th Street, Richmond, VA 23219 Sabnis, Ashwini S. PhD*, University of Utah, Center for Human Toxicology, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108; and Diana G. Wilkins, PhD, Center for Human Toxicology, Biomed Research Polymers Building, Room 490, Salt Lake City, UT 84112 Samojlik, Isidora PhD*, Department of Pharmacology and Toxicology, Faculty of Medicine, Department of Pharmacology, Faculty of Medicine, Hajduk Veljkova 3, Novi Sad, 21000, SERBIA AND MONTENEGRO; Stojan Petkovic, PhD, Klinicki centar Vojvodina, Department of Forensic Medicine, Clinical Center of Vojvodina, Hajduk Veljkova 5-7, Novi Sad, 21000, SERBIA AND MONTENEGRO; Maja Durendic-Brenesel, PhD, Klinicki centar Vojvodine, Department of Forensic Medicine, Clinical Center of Vojvodina, Hajduk Veljkova 5-7, Novi Sad, 21000, SERBIA AND MONTENEGRO; Matilda Dolai, PhD, Klinicki centar Vojvodine, Department of Pathology, Clinical Center of Vojvodina, Hajduk Veljkova 5-7, Novi Sad, 2100, SERBIA AND MONTENEGRO Sasaki, Tania A. PhD*, and Claire J. Bramwell-German, PhD, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404; and Sumandeep Rana, MS and Wayne B. Ross, MCLS, Redwood Toxicology Laboratory, 3650 Westwind Boulevard, Santa Rosa, CA 95403 Sasaki, Tania A. PhD*, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404; and Dea Boehme, Keith Nakagawa, and Fabiola Nunes-Daniel, Ventura County Sheriff’s Crime Lab, 800 South Victoria Avenue, Ventura, CA 93009 Index 104 Common Heroin Adulterants in Puerto Rico: The Emergence of Xylazine Driving Under the Influence of Drugs (DUID) Testing Protocol in the Commonwealth of Virginia Instances of Marijuana, Driving, Blood Concentrations, Field Sobriety Tests, and Prediction Models Quantitative Determination of SSRI Drugs and Metabolites in Human Plasma by SPE- LC-MS/MS Fatal Intoxication Due to Trihexyphenidyl - A Case Report A Quick LC/MS/MS Method for the Analysis of Common Benzodiazepines and Opiates Analysis of THC and Its Metabolites Utilizing LC/MS/MS 78 151 110 58 25 60 164
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FORENSIC TOXICOLOGY Proceedings 200
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Forensic Toxicology iii
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Preface The American Academy of For
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Toxiclogy Board of Directors Repres
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Development & Accreditation; Tracie
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Analysis of Amphetamine on Swabs an
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Evaluation of Enzymatic Hydrolysis
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Identification of Markers of JWH-01
Page 18 and 19:
Cannabinoid Concentrations in Daily
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Alcohol Elimination Rate Variabilit
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Preparation of Oral Fluid for Quant
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Postmortem Pediatric Toxicology Rob
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A Quick LC/MS/MS Method for the Ana
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Fatal Death of an 8-Year-Old Boy Fr
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Nine Xylazine Related Deaths in Pue
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Gas Chromatography of Postmortem Bl
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Specificity Characteristics of Bupr
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Disposition of MDMA and Metabolites
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Determination of Trace Levels of Be
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Whole Blood/Plasma Cannabinoid Rati
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Prevalence of Cocaine on Urban and
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Intoxilyzer® 8000 Stability Study
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The Role of the Forensic Expert in
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Clinical vs. Forensic Toxicology -
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Comparative Analysis of GHB and GHV
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Toxicology of Deaths Associated Wit
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Determination of Toxins and Alkaloi
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Bupropion and Its Metabolites in Tw
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Use of a Novel Large Volume Splitle
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Death Due to Ingestion of Tramadol
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A Multi-Drug Fatality Involving the
Page 64 and 65: Urinary Excretion of α-Hydroxytria
Page 66 and 67: Analysis of Barbiturates by Fast GC
Page 68 and 69: A Review of Postmortem Diltiazem Co
Page 70 and 71: Analysis of Drugs From Paired Hair
Page 72 and 73: Index by Presenting Author Author b
Page 74 and 75: Virginia Street, West, Charleston,
Page 76 and 77: Bévalot, Fabien MD*, Laboratoire L
Page 78 and 79: C. Bishop BS*, Sandra Bruce R. McCo
Page 80 and 81: Chen, Bud-gen BS, Fooyin University
Page 82 and 83: Couper, Fiona J. PhD*, and Rory M.
Page 84 and 85: Drees, Julia C. PhD*, Judy A. Stone
Page 86 and 87: Furton, Kenneth G. PhD, Internation
Page 88 and 89: Gray, Teresa R. MS*, National Insti
Page 90 and 91: Halphen, Aimee M. MS*, and C. Richa
Page 92 and 93: Huestis, Marilyn A. PhD, David A. G
Page 94 and 95: Jufer, Rebecca A. PhD*, Barry S. Le
Page 96 and 97: Kim, Nam Yee PhD*, National Institu
Page 98 and 99: Langman, Loralie J. PhD*, Provincia
Page 100 and 101: Li, Ling MD, and Xiang Zhang, MD*,
Page 102 and 103: Lougee, Kevin M. BS*, Amy L. Lais,
Page 104 and 105: Mercan, Selda MSc, Institute of For
Page 106 and 107: Miles, Harry L. JD*, Green, Miles,
Page 108 and 109: Negrusz, Adam PhD, DSc*, Bindu K. S
Page 110 and 111: Peters, DeMia E. MS*, Liqun L. Wong
Page 112 and 113: Rajotte, James W. MSc*, Centre of F
Page 116 and 117: Sasaki, Tania A. PhD*, Applied Bios
Page 118 and 119: Shakleya, Diaa M. PhD*, West Virgin
Page 120 and 121: Staretz, Marianne E. PhD, Departmen
Page 122 and 123: Swofford*, Henry J. 4207 Coatsworth
Page 124 and 125: Wagner, Michael MS, PA*, Harold E.
Page 126 and 127: Winterling, Jill M. BS*, Richard T.
Page 128 and 129: Index 117
Page 130 and 131: ange of years studied, drugs appear
Page 132 and 133: K6 Simultaneous Detection of Psyche
Page 134 and 135: K10 Analysis of Hydrocodone, Hydrom
Page 136 and 137: A cleanup tip was developed that is
Page 138 and 139: Eurachem method. Validation results
Page 140 and 141: tetrathiocynates and further determ
Page 142 and 143: K26 An Investigation Into the Cellu
Page 144 and 145: important of quickly identifying th
Page 146 and 147: K33 Detection of Various Performanc
Page 148 and 149: K36 The Uncertainty of Hair Analysi
Page 150 and 151: Results: The Intercept® device col
Page 152 and 153: collected on days 22-31, 14.8% rema
Page 154 and 155: concentrations of glucose and lacta
Page 156 and 157: A 48-year-old male was found dead o
Page 158 and 159: TOXICOLOGY Seattle 2010 Seattle 201
Page 160 and 161: scientists, as well as the importan
Page 162 and 163: toxicology in suspected narcotic ov
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Blood * Presenting Author Oxycodone
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According to the routine screening
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particle) analytical column operate
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ventilated low-lying areas. Inhalat
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may be relevant to forensic toxicol
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and one case had combined caffeine
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(16.9%), flunitrazepam (15.7%) and
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end of the run. Comparison of the r
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K42 Melendez-Diaz and Other 6th Ame
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In developing a full panel of DFSA
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including equilibration time. MS/MS
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ng/ml. The upper limit of quantitat
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to 18-years-old. Ten of the samples
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to 200 mg/dL. Samples above the lin
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which is used to relieve moderate t
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lab for drug and alcohol screening.
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elated fatalities. Methamphetamine,
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explosion. Toxicological analyses w
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and GC-MS, plus drug class specific
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incidence of methamphetamine in all
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K42 Homicide by Propofol Martha J.
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K45 Common Heroin Adulterants in Pu
Page 208 and 209:
K48 Evaluation of Alcohol Markers i
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The color formation with the ferric
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explored. Opioids were chosen for a
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including pharmaco-toxicokinetic da
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of compounds typically found in ill
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Discussion: When investigating a to
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qualifier ratios. Samples containin
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BG and some cross-reactivity toward
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concentrations, almost invariably t
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nitrogen. Qualitative analysis was
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LC/MS/MS for analysis of benzodiaze
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were analyzed with each batch of sa
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concentration will decrease signifi
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and the meprobamate. To explain thi
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plasma drug concentrations. Oral fl
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significant correlation existed bet
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to an increase in the frequency of
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matrix despite extensive mixing pri
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y SPE (Clean Screen ® ZSTHC020 ext
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0.18 mg/L in aortic blood and 2.1 m
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munoassay. Identification and quant
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The fluctuations in the child’s u
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AMP BZE OPI PCP THCA ADULT INV SUBS
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Table I. Postmortem Distribution of
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K9 Fatal Ephedrine Intoxication in
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without any chromatography, resulti
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In the “direct” application of
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K21 Evaluation of the Immunalysis®
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fibrillation (VF) induction using t
Page 266 and 267:
K28 Driving Under the Influence (DU
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K31 Methadone and Impaired Driving
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of Criminal Procedure was likewise
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Case #1: A 12-year-old female was f
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As seen in the above data, there ha
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determination of methamphetamine fr
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K48 Rapid Analysis of THC and Metab
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(0.09 mg/L). The accused drove over
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necessity. Information pertaining t
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K6 Determination of 2-Chloracetophe
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K8 Simultaneous Determination of HF
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This presentation will impact the f
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K16 Fentanyl Concentrations in 23 P
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Table 2 - GC Results Analyte LOD LO
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In America, recent growth in the po
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to fully prosecute the case, negoti
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dictive for the time of use. The ti
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absence, or cursory forms, of such
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Atomoxetine can be considered non-t
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nickel catalyst and detected with a
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Sample ID Hair result (pg/mg) Urine
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prevalence was compared with the do
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K1 Determination of Toxins and Alka
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toxicological profiles of the deced
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ecords were reviewed for all deaths
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K15 Performance Characteristics of
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analyzed by GC/MS with separation o
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This presentation will provide a fu
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tubing ran from the container throu
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murder and is often initially misdi
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K35 Interpretation of Glucose and L
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K38 Drugs in Driving Fatalities in
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jDALLA Toxicology j2004 K1 Use of a
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manufacturer. Analysis of samples f
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K9 An Analytical Protocol for the I
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K13 Laboratory Analysis of Remotely
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K15 Postmortem Production of Ethano
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K18 The Effects of pH on the Oxidat
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directed into an electrospray ioniz
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K25 The Detection of Oxycodone in M
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Hair analysis revealed the presence
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K32 Detection of Ketamine in Urine
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Conversations with two MDMA / MDA c
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The concentrations of total ropivac
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clozapine and metabolite in the cas
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(except in exceptionally high doses
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y pulmonary edema and a rapid cardi
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Toxicology K1 Urinary Excretion of
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presumptive pneumonia, and administ
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K7 Optimizing HPLC Separation of An
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and quantitative determination of M
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with BSTFA. Quantitation was perfor
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compounds contained in the current
Page 372 and 373:
Fast gas chromatography (GC) has th
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importance to law enforcement agenc
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tramadol, closely followed by amitr
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acid. Oxalic and formic acids are f
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interaction involves activation of
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intake. Also, the positive serum an
Page 384 and 385:
K1 A Review of Postmortem Diltiazem
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The concentration of interferent re
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three principal media, viz., blood,
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Of the tricyclic antidepressants, a
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Table 1. Effect of reconstitution v
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corticosteroids: cortisol and corti
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Hair specimens aligned in a foil en
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eference solution of each olanzapin
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presented. In the first case, a 31-
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combination with alcohol. From 1997
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Urine specimens were spiked with th
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