FORENSIC TOXICOLOGY - Bio Medical Forensics

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Toxiclogy Board of Directors Representatives and Chairs Director vii Chair 2011-2012 Jeri D. Ropero-Miller, PhD Philip M. Kemp, PhD 2010-2011 Marilyn A. Huestis, PhD Kenneth E. Ferslew, PhD 2009-2010 Marilyn A. Huestis, PhD Jeri D. Ropero-Miller, PhD 2008-2009 Marilyn A. Huestis, PhD Peter R. Stout, PhD 2007-2008 Barry K. Logan, PhD Robert A. Middleberg, PhD 2006-2007 Barry K. Logan, PhD Adam Negrusz, PhD 2005-2006 Barry K. Logan, PhD Timothy P. Rohrig, PhD 2004-2005 Daniel S. Isenschmid, PhD Amanda J. Jenkins, PhD 2003-2004 Daniel S. Isenschmid, PhD Christine Moore, PhD 2002-2003 Daniel S. Isenschmid, PhD Joseph J. Saady, PhD 2001-2002 Bruce A. Goldberger, PhD Bradford R. Helpler, PhD 2000-2001 Bruce A. Goldberger, PhD Barry K. Logan, PhD 1999-2000 Bruce A. Goldberger, PhD Marilyn A. Huestis, PhD 1998-1999 Vickie Watts, MS Daniel S. Isenschmid, PhD 1997-1998 Vickie Watts, MS William L. Hearn, PhD 1996-1997 Vickie Watts, MS Bruce A. Goldberger, PhD 1995-1996 Graham R. Jones, PhD C. Nicholas Hodnett, PhD 1994-1995 Graham R. Jones, PhD H. Horton McCurdy, PhD 1993-1994 Graham R. Jones, PhD Vickie W. Watts, MS 1992-1993 Michael I. Schaffer, PhD Patricia H. Field, PhD 1991-1992 Michael I. Schaffer, PhD Graham R. Jones, PhD 1990-1991 Michael I. Schaffer, PhD Alphonse Poklis, PhD 1989-1990 Michael A. Peat, PhD J. Rod McCutcheon, BS 1988-1989 Michael A. Peat, PhD Michael I. Schaffer, PhD 1987-1988 Michael A. Peat, PhD Leonard R. Bednarczyk, PhD 1986-1987 Marina Stajic, PhD Ronald C. Backer, PhD 1985-1986 Marina Stajic, PhD Michael A. Peat, PhD 1984-1985 Marina Stajic, PhD Richard F. Shaw, BS 1983-1984 Yale H. Caplan, PhD Joseph Balkon, PhD 1982-1983 Yale H. Caplan, PhD Marina Stajic, PhD 1981-1982 Yale H. Caplan, PhD Joseph R. Monforte, PhD 1980-1981 Yale H. Caplan, PhD James C. Garriott, PhD 1979-1980 Robert H. Cravey, MS Yale H. Caplan, PhD 1978-1979 Robert H. Cravey, MS Naresh C. Jain, PhD
1977-1978 Robert V. Blanke, PhD George R. Nakamura, PhD 1976-1977 Robert V. Blanke, PhD Robert H. Cravey, MS 1975-1976 Robert V. Blanke, PhD Robert H. Cravey, MS 1974-1975 June K. Jones, MS Leo A. Dal Cortivo, PhD 1973-1974 June K. Jones, MS Bryan S. Finkle, PhD 1972-1973 June K. Jones, MS Richard W. Prouty, BS 1971-1972 Abraham Stolman, PhD June K. Jones, MS 1970-1971 Abraham Stolman, PhD June K. Jones, MS 1969-1970 Abel M. Dominguez, PhD 1968-1969 Kurt M. Dubowski, PhD Abel M. Dominguez, PhD 1967-1968 Arthur J. McBay, PhD 1966-1967 Kurt M. Dubowski, PhD / Robert B. Forney, PhD Arthur J. McBay, PhD 1965-1966 Fredric Rieders, PhD 1964-1965 H. Ward Smith, PhD 1963-1964 Carl J. Rehling, PhD, LLB 1962-1963 Morton F. Mason, PhD 1961-1962 Morton F. Mason, PhD 1960-1961 Kurt M. Dubowski, PhD 1959-1960 Irving Sunshine, PhD 1958-1959 Irving Sunshine, PhD 1957-1958 Henry C. Freimuth, PhD 1956-1957 Henry C. Freimuth, PhD 1955-1956 Henry C. Freimuth, PhD 1954-1955 Robert B. Forney, PhD 1953-1954 Robert B. Forney, PhD 1952-1953 A.W. Freireich, MD 1951-1952 A.W. Freireich, MD 1950-1951 A.W. Freireich, MD Our heartfelt thanks to the Academy Staff for managing the proceedings process that results in the highest standards of quality including Sonya Bynoe, Publications & Website Coordinator; Debbie Crockett, Finance Manager; Sondra Doolittle, Meetings & Exposition Manager; Phyllis Gilliam, Receptionist; Salena Grant, Assistant Meetings Manager; Cheryl Hunter, Membership Coordinator; Nancy Jackson, Director of viii
Page 1 and 2: FORENSIC TOXICOLOGY Proceedings 200
Page 4 and 5: Forensic Toxicology iii
Page 6 and 7: Preface The American Academy of For
Page 10 and 11: Development & Accreditation; Tracie
Page 12 and 13: Analysis of Amphetamine on Swabs an
Page 14 and 15: Evaluation of Enzymatic Hydrolysis
Page 16 and 17: Identification of Markers of JWH-01
Page 18 and 19: Cannabinoid Concentrations in Daily
Page 20 and 21: Alcohol Elimination Rate Variabilit
Page 22 and 23: Preparation of Oral Fluid for Quant
Page 24 and 25: Postmortem Pediatric Toxicology Rob
Page 26 and 27: A Quick LC/MS/MS Method for the Ana
Page 28 and 29: Fatal Death of an 8-Year-Old Boy Fr
Page 30 and 31: Nine Xylazine Related Deaths in Pue
Page 32 and 33: Gas Chromatography of Postmortem Bl
Page 34 and 35: Specificity Characteristics of Bupr
Page 36 and 37: Disposition of MDMA and Metabolites
Page 38 and 39: Determination of Trace Levels of Be
Page 40 and 41: Whole Blood/Plasma Cannabinoid Rati
Page 42 and 43: Prevalence of Cocaine on Urban and
Page 44 and 45: Intoxilyzer® 8000 Stability Study
Page 46 and 47: The Role of the Forensic Expert in
Page 48 and 49: Clinical vs. Forensic Toxicology -
Page 50 and 51: Comparative Analysis of GHB and GHV
Page 52 and 53: Toxicology of Deaths Associated Wit
Page 54 and 55: Determination of Toxins and Alkaloi
Page 56 and 57: Bupropion and Its Metabolites in Tw
Page 58 and 59:
Use of a Novel Large Volume Splitle
Page 60 and 61:
Death Due to Ingestion of Tramadol
Page 62 and 63:
A Multi-Drug Fatality Involving the
Page 64 and 65:
Urinary Excretion of α-Hydroxytria
Page 66 and 67:
Analysis of Barbiturates by Fast GC
Page 68 and 69:
A Review of Postmortem Diltiazem Co
Page 70 and 71:
Analysis of Drugs From Paired Hair
Page 72 and 73:
Index by Presenting Author Author b
Page 74 and 75:
Virginia Street, West, Charleston,
Page 76 and 77:
Bévalot, Fabien MD*, Laboratoire L
Page 78 and 79:
C. Bishop BS*, Sandra Bruce R. McCo
Page 80 and 81:
Chen, Bud-gen BS, Fooyin University
Page 82 and 83:
Couper, Fiona J. PhD*, and Rory M.
Page 84 and 85:
Drees, Julia C. PhD*, Judy A. Stone
Page 86 and 87:
Furton, Kenneth G. PhD, Internation
Page 88 and 89:
Gray, Teresa R. MS*, National Insti
Page 90 and 91:
Halphen, Aimee M. MS*, and C. Richa
Page 92 and 93:
Huestis, Marilyn A. PhD, David A. G
Page 94 and 95:
Jufer, Rebecca A. PhD*, Barry S. Le
Page 96 and 97:
Kim, Nam Yee PhD*, National Institu
Page 98 and 99:
Langman, Loralie J. PhD*, Provincia
Page 100 and 101:
Li, Ling MD, and Xiang Zhang, MD*,
Page 102 and 103:
Lougee, Kevin M. BS*, Amy L. Lais,
Page 104 and 105:
Mercan, Selda MSc, Institute of For
Page 106 and 107:
Miles, Harry L. JD*, Green, Miles,
Page 108 and 109:
Negrusz, Adam PhD, DSc*, Bindu K. S
Page 110 and 111:
Peters, DeMia E. MS*, Liqun L. Wong
Page 112 and 113:
Rajotte, James W. MSc*, Centre of F
Page 114 and 115:
Ropero-Miller, Jeri D. PhD*, RTI In
Page 116 and 117:
Sasaki, Tania A. PhD*, Applied Bios
Page 118 and 119:
Shakleya, Diaa M. PhD*, West Virgin
Page 120 and 121:
Staretz, Marianne E. PhD, Departmen
Page 122 and 123:
Swofford*, Henry J. 4207 Coatsworth
Page 124 and 125:
Wagner, Michael MS, PA*, Harold E.
Page 126 and 127:
Winterling, Jill M. BS*, Richard T.
Page 128 and 129:
Index 117
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ange of years studied, drugs appear
Page 132 and 133:
K6 Simultaneous Detection of Psyche
Page 134 and 135:
K10 Analysis of Hydrocodone, Hydrom
Page 136 and 137:
A cleanup tip was developed that is
Page 138 and 139:
Eurachem method. Validation results
Page 140 and 141:
tetrathiocynates and further determ
Page 142 and 143:
K26 An Investigation Into the Cellu
Page 144 and 145:
important of quickly identifying th
Page 146 and 147:
K33 Detection of Various Performanc
Page 148 and 149:
K36 The Uncertainty of Hair Analysi
Page 150 and 151:
Results: The Intercept® device col
Page 152 and 153:
collected on days 22-31, 14.8% rema
Page 154 and 155:
concentrations of glucose and lacta
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A 48-year-old male was found dead o
Page 158 and 159:
TOXICOLOGY Seattle 2010 Seattle 201
Page 160 and 161:
scientists, as well as the importan
Page 162 and 163:
toxicology in suspected narcotic ov
Page 164 and 165:
Blood * Presenting Author Oxycodone
Page 166 and 167:
According to the routine screening
Page 168 and 169:
particle) analytical column operate
Page 170 and 171:
ventilated low-lying areas. Inhalat
Page 172 and 173:
may be relevant to forensic toxicol
Page 174 and 175:
and one case had combined caffeine
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(16.9%), flunitrazepam (15.7%) and
Page 178 and 179:
end of the run. Comparison of the r
Page 180 and 181:
K42 Melendez-Diaz and Other 6th Ame
Page 182 and 183:
In developing a full panel of DFSA
Page 184 and 185:
including equilibration time. MS/MS
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ng/ml. The upper limit of quantitat
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to 18-years-old. Ten of the samples
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to 200 mg/dL. Samples above the lin
Page 192 and 193:
which is used to relieve moderate t
Page 194 and 195:
lab for drug and alcohol screening.
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elated fatalities. Methamphetamine,
Page 198 and 199:
explosion. Toxicological analyses w
Page 200 and 201:
and GC-MS, plus drug class specific
Page 202 and 203:
incidence of methamphetamine in all
Page 204 and 205:
K42 Homicide by Propofol Martha J.
Page 206 and 207:
K45 Common Heroin Adulterants in Pu
Page 208 and 209:
K48 Evaluation of Alcohol Markers i
Page 210 and 211:
The color formation with the ferric
Page 212 and 213:
explored. Opioids were chosen for a
Page 214 and 215:
including pharmaco-toxicokinetic da
Page 216 and 217:
of compounds typically found in ill
Page 218 and 219:
Discussion: When investigating a to
Page 220 and 221:
qualifier ratios. Samples containin
Page 222 and 223:
BG and some cross-reactivity toward
Page 224 and 225:
concentrations, almost invariably t
Page 226 and 227:
nitrogen. Qualitative analysis was
Page 228 and 229:
LC/MS/MS for analysis of benzodiaze
Page 230 and 231:
were analyzed with each batch of sa
Page 232 and 233:
concentration will decrease signifi
Page 234 and 235:
and the meprobamate. To explain thi
Page 236 and 237:
plasma drug concentrations. Oral fl
Page 238 and 239:
significant correlation existed bet
Page 240 and 241:
to an increase in the frequency of
Page 242 and 243:
matrix despite extensive mixing pri
Page 244 and 245:
y SPE (Clean Screen ® ZSTHC020 ext
Page 246 and 247:
0.18 mg/L in aortic blood and 2.1 m
Page 248 and 249:
munoassay. Identification and quant
Page 250 and 251:
The fluctuations in the child’s u
Page 252 and 253:
AMP BZE OPI PCP THCA ADULT INV SUBS
Page 254 and 255:
Table I. Postmortem Distribution of
Page 256 and 257:
K9 Fatal Ephedrine Intoxication in
Page 258 and 259:
without any chromatography, resulti
Page 260 and 261:
In the “direct” application of
Page 262 and 263:
K21 Evaluation of the Immunalysis®
Page 264 and 265:
fibrillation (VF) induction using t
Page 266 and 267:
K28 Driving Under the Influence (DU
Page 268 and 269:
K31 Methadone and Impaired Driving
Page 270 and 271:
of Criminal Procedure was likewise
Page 272 and 273:
Case #1: A 12-year-old female was f
Page 274 and 275:
As seen in the above data, there ha
Page 276 and 277:
determination of methamphetamine fr
Page 278 and 279:
K48 Rapid Analysis of THC and Metab
Page 280 and 281:
(0.09 mg/L). The accused drove over
Page 282 and 283:
necessity. Information pertaining t
Page 284 and 285:
K6 Determination of 2-Chloracetophe
Page 286 and 287:
K8 Simultaneous Determination of HF
Page 288 and 289:
This presentation will impact the f
Page 290 and 291:
K16 Fentanyl Concentrations in 23 P
Page 292 and 293:
Table 2 - GC Results Analyte LOD LO
Page 294 and 295:
In America, recent growth in the po
Page 296 and 297:
to fully prosecute the case, negoti
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dictive for the time of use. The ti
Page 300 and 301:
absence, or cursory forms, of such
Page 302 and 303:
Atomoxetine can be considered non-t
Page 304 and 305:
nickel catalyst and detected with a
Page 306 and 307:
Sample ID Hair result (pg/mg) Urine
Page 308 and 309:
prevalence was compared with the do
Page 310 and 311:
K1 Determination of Toxins and Alka
Page 312 and 313:
toxicological profiles of the deced
Page 314 and 315:
ecords were reviewed for all deaths
Page 316 and 317:
K15 Performance Characteristics of
Page 318 and 319:
analyzed by GC/MS with separation o
Page 320 and 321:
This presentation will provide a fu
Page 322 and 323:
tubing ran from the container throu
Page 324 and 325:
murder and is often initially misdi
Page 326 and 327:
K35 Interpretation of Glucose and L
Page 328 and 329:
K38 Drugs in Driving Fatalities in
Page 330 and 331:
jDALLA Toxicology j2004 K1 Use of a
Page 332 and 333:
manufacturer. Analysis of samples f
Page 334 and 335:
K9 An Analytical Protocol for the I
Page 336 and 337:
K13 Laboratory Analysis of Remotely
Page 338 and 339:
K15 Postmortem Production of Ethano
Page 340 and 341:
K18 The Effects of pH on the Oxidat
Page 342 and 343:
directed into an electrospray ioniz
Page 344 and 345:
K25 The Detection of Oxycodone in M
Page 346 and 347:
Hair analysis revealed the presence
Page 348 and 349:
K32 Detection of Ketamine in Urine
Page 350 and 351:
Conversations with two MDMA / MDA c
Page 352 and 353:
The concentrations of total ropivac
Page 354 and 355:
clozapine and metabolite in the cas
Page 356 and 357:
(except in exceptionally high doses
Page 358 and 359:
y pulmonary edema and a rapid cardi
Page 360 and 361:
Toxicology K1 Urinary Excretion of
Page 362 and 363:
presumptive pneumonia, and administ
Page 364 and 365:
K7 Optimizing HPLC Separation of An
Page 366 and 367:
and quantitative determination of M
Page 368 and 369:
with BSTFA. Quantitation was perfor
Page 370 and 371:
compounds contained in the current
Page 372 and 373:
Fast gas chromatography (GC) has th
Page 374 and 375:
importance to law enforcement agenc
Page 376 and 377:
tramadol, closely followed by amitr
Page 378 and 379:
acid. Oxalic and formic acids are f
Page 380 and 381:
interaction involves activation of
Page 382 and 383:
intake. Also, the positive serum an
Page 384 and 385:
K1 A Review of Postmortem Diltiazem
Page 386 and 387:
The concentration of interferent re
Page 388 and 389:
three principal media, viz., blood,
Page 390 and 391:
Of the tricyclic antidepressants, a
Page 392 and 393:
Table 1. Effect of reconstitution v
Page 394 and 395:
corticosteroids: cortisol and corti
Page 396 and 397:
Hair specimens aligned in a foil en
Page 398 and 399:
eference solution of each olanzapin
Page 400 and 401:
presented. In the first case, a 31-
Page 402 and 403:
combination with alcohol. From 1997
Page 404:
Urine specimens were spiked with th
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