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OR/11/013 which relate to living organisms. The hazards associated with specific types of contaminants are discussed in Chapter 3. In Box 1 we review toxicological approaches to prioritising emerging contaminants. 2.3.1 Toxicity The harmful effects of chemicals can be evaluated in a number of ways. The acute toxicity of a chemical refers to its ability to do harm as a result of a single short exposure. This is likely to be relevant to accidents and spillages where the impact on health is rapid. Chronic toxicity refers to the ability of a chemical to do damage as a result of repeated or prolonged exposure, for example in an industrial environment or through food or drinking water. The chronic effects of a substance can be classified into various types, such as: toxicity (ability to cause unspecified harm); carcinogenicity (ability to produce tumours); mutagenicity (ability to cause alteration of genetic material) and teratogenicity (effects on the foetus). Genotoxic carcinogens, which are considered to pose the greatest risk to humans, cause cancer by interfering with genetic information in the affected cells. Other potential effects are allergies and disruption of the immune and nervous systems. The toxic effects can be used to prioritise pollutant monitoring (Box 1). 2.3.2 Endocrine disruption Substances which may not be directly toxic may have the ability to interfere with natural hormone actions and are known as endocrine disruptors. Endocrine substances which may be disrupted include: oestrogens – provide the stimulus for growth, development and function of the female reproductive tract. The principal oestrogen in vertebrates is 17-oestrodiol androgens – produce masculine characteristics, the development of skeletal muscle and bone and the development of the male reproductive organs thyroid hormones – regulate almost all vital organs and functions, controlling development and metabolic activity neurohormones – released from the hypothalamus and maintain the functioning of the endocrine system Oestrogenic endocrine disrupting substances include: alkylphenol polyethoxylates, (APEs) alkyl phenols, phthalates, and bisphenolic compounds. Pesticides may also have androgenic and hypothalmic activity. 4
OR/11/013 Box 1 Toxicological approaches to prioritising emerging contaminants In their editorial to the special issue of Water Research ‘Emerging contaminants in water’ Ternes and von Gunten (2010) state that to elucidate the relevance of micropollutants in aquatic systems their (eco)toxicological potential must be addressed. Schriks et al. (2010) assessed a range of emerging contaminants detected in groundwater and surface water in the Rhine and Meuse basins. Only relatively polar compounds were considered (Kow
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Page 4 and 5: BRITISH GEOLOGICAL SURVEY The full
Page 6 and 7: OR/11/013 Contents Foreword i Ackno
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OR/11/013 6.2 PREDICTING RISK FROM
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OR/11/013 No of detections 1200 100
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OR/11/013 CHLORINATED SOLVENTS AND
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OR/11/013 and benz[a]anthracene det
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OR/11/013 7.2.3 Specific priority c
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OR/11/013 Figure 7.8 Hotspot of DEE
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OR/11/013 7.3 CONCLUSIONS FROM ENVI
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OR/11/013 Table 8.1 Pollutants esta
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OR/11/013 9 Conclusions and recomme
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OR/11/013 References ABE, A. 1999.
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OR/11/013 CLARA, M, STRENN, B, and
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OR/11/013 HEKSTER, F M, LAANE, R W
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OR/11/013 LAM, M, YOUNG, C, BRAIN,
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OR/11/013 PURDOM, C E, HARDIMAN, P
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OR/11/013 USEPA. 2006. 2006 Edition
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OR/11/013 Glossary of acronyms Acro
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OR/11/013 Glossary of symbols Symbo
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OR/11/013 Parent Metabolite Methioc
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OR/11/013 Table A3 Key metabolites
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OR/11/013 Appendix 2 Summary of com
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OR/11/013 Table A2.3 Pharmaceutical
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OR/11/013 Table A2.7 Alkyl phosphat
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OR/11/013 A3.7 SPECIFIC CONTAMINANT
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