Antiemetics for reducing vomiting related to acute ... - Update Software

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Analysis 1.5. Comparison 1 Oral ondansetron (weight dependent dose) vs placebo, Outcome 5 Rate of intravenous rehydration (up to 72 hrs following discharge from the ED stay), best-worst case scenario. Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents Comparison: 1 Oral ondansetron (weight dependent dose) vs placebo Outcome: 5 Rate of intravenous rehydration (up to 72 hrs following discharge from the ED stay), best-worst case scenario Study or subgroup Ondansetron Placebo Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Freedman 2006 26/107 39/103 46.3 % 0.64 [ 0.42, 0.97 ] Ramsook 2002 6/74 16/71 19.0 % 0.36 [ 0.15, 0.87 ] Roslund 2008 13/51 31/55 34.7 % 0.45 [ 0.27, 0.76 ] Total (95% CI) 232 229 100.0 % 0.52 [ 0.38, 0.71 ] Total events: 45 (Ondansetron), 86 (Placebo) Heterogeneity: Chi 2 = 1.92, df = 2 (P = 0.38); I 2 =0.0% Test for overall effect: Z = 4.16 (P = 0.000031) Test for subgroup differences: Not applicable 0.01 0.1 1 10 100 Favours ondansetron Favours placebo Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 52
Analysis 1.6. Comparison 1 Oral ondansetron (weight dependent dose) vs placebo, Outcome 6 Rate of intravenous rehydration (up to 72 hrs following discharge from the ED stay), worst-best case scenario. Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents Comparison: 1 Oral ondansetron (weight dependent dose) vs placebo Outcome: 6 Rate of intravenous rehydration (up to 72 hrs following discharge from the ED stay), worst-best case scenario Study or subgroup Ondansetron Placebo Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Freedman 2006 26/107 39/103 46.3 % 0.64 [ 0.42, 0.97 ] Ramsook 2002 10/74 16/71 19.0 % 0.60 [ 0.29, 1.23 ] Roslund 2008 13/51 31/55 34.7 % 0.45 [ 0.27, 0.76 ] Total (95% CI) 232 229 100.0 % 0.57 [ 0.42, 0.76 ] Total events: 49 (Ondansetron), 86 (Placebo) Heterogeneity: Chi 2 = 1.08, df = 2 (P = 0.58); I 2 =0.0% Test for overall effect: Z = 3.74 (P = 0.00018) Test for subgroup differences: Not applicable 0.01 0.1 1 10 100 Favours ondansetron Favours placebo Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 53
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Antiemetics for reducing vomiting r
Page 3 and 4: [Intervention Review] Antiemetics f
Page 5 and 6: S U M M A R Y O F F I N D I N G S F
Page 7 and 8: GRADEWorkingGroupgradesofevidence.
Page 9 and 10: Why it is important to do this revi
Page 11 and 12: confidence intervals (CI) and P val
Page 13 and 14: Figure 1. Study flow diagram (PRISM
Page 15 and 16: participants in Freedman 2006 and R
Page 17 and 18: Figure 3. Risk of bias summary: rev
Page 19 and 20: All of the studies with the excepti
Page 21 and 22: esults were similar and the conclus
Page 23 and 24: Primary outcomes Time taken from th
Page 25 and 26: D I S C U S S I O N Overall complet
Page 27 and 28: severity of disease; and on outcome
Page 29 and 30: and Adolescent Medicine 2003;157(5)
Page 31 and 32: Cubeddu 1997 (Continued) Risk of bi
Page 33 and 34: Freedman 2006 (Continued) dependent
Page 35 and 36: Ramsook 2002 (Continued) Bias Autho
Page 37 and 38: Roslund 2008 (Continued) Notes Quot
Page 39 and 40: Stork 2006 (Continued) REHYDRATION
Page 41 and 42: Uhlig 2009 (Continued) Intervention
Page 43 and 44: Yilmaz 2010 (Continued) • Nonbili
Page 45 and 46: Yilmaz 2010 (Continued) Other bias
Page 47 and 48: NCT01165866 (Continued) Participant
Page 49 and 50: D A T A A N D A N A L Y S E S Compa
Page 51 and 52: Analysis 1.2. Comparison 1 Oral ond
Page 53: Analysis 1.4. Comparison 1 Oral ond
Page 57 and 58: Analysis 1.8. Comparison 1 Oral ond
Page 59 and 60: Table 5. Random-effects sensitivity
Page 61 and 62: Table 15. Parental satisfaction/imp
Page 63 and 64: A P P E N D I C E S Appendix 1. Sea
Page 65 and 66: Appendix 3. CENTRAL search strategy
Page 67 and 68: 48. exp child/ or child$.tw. 49. ex
Page 69 and 70: or hexadecadrol or hexadrol or loka
Page 71 and 72: 51. (promethazine or Avomine or adg
Page 73 and 74: W H A T ’ S N E W Last assessed a
Page 75 and 76: S O U R C E S O F S U P P O R T Int
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