Antiemetics for reducing vomiting related to acute ... - Update Software

Analysis 1.8. Comparison 1 Oral ondansetron (weight dependent dose) vs placebo, Outcome 8 Revisit rate.
Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents
Comparison: 1 Oral ondansetron (weight dependent dose) vs placebo
Outcome: 8 Revisit rate
Study or subgroup Ondansetron Placebo Risk Ratio Weight Risk Ratio
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Freedman 2006 20/105 22/101 90.2 % 0.87 [ 0.51, 1.50 ]
Ramsook 2002 4/74 0/71 2.1 % 8.64 [ 0.47, 157.62 ]
Roslund 2008 3/51 2/55 7.7 % 1.62 [ 0.28, 9.29 ]
Total (95% CI) 230 227 100.0 % 1.09 [ 0.66, 1.79 ]
Total events: 27 (Ondansetron), 24 (Placebo)
Heterogeneity: Chi 2 = 2.79, df = 2 (P = 0.25); I 2 =28%
Test for overall effect: Z = 0.35 (P = 0.73)
Test for subgroup differences: Not applicable
A D D I T I O N A L T A B L E S
0.01 0.1 1 10 100
Favours ondansetron Favours placebo
Table 1. Admission, IV rehydration, and revisit rates (Freedman 2006)
Ondansetron Placebo
Admission rate (during ED stay) 4/107 5/107
Admission rate (Day 3) 10/107 11/103
IV rehydration rate (during ED stay) 15/107 33/107
IV rehydration (Day 3) 26/107 39/103
Revisit rate 20/105 22/101
Table 2. Admission, IV rehydration, and revisit rates (Ramsook 2002)
Ondansetron Placebo
Admission rate (during ED stay) 2/74 11/71
Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review)
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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