Antiemetics for reducing vomiting related to acute ... - Update Software

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Ondansetron reducedthe intravenous rehydration rateduringtheEDstay ⊕⊕⊕○ moderate1 465 (3studies) Studypopulation RR0.41 (0.29to0.59) Rate of intravenous rehydrationduringEDstay 339per1000 139per1000 (98to200) ⊕⊕○○ low1,2 461 (3studies) Studypopulation RR0.52 (0.38to0.1) 376per1000 196per1000 (143to38) Rate of intravenous rehydration up to 72 hrs followingdischargefrom ED (best - worst scenario) ⊕⊕○○ low1,2 461 (3studies) Studypopulation RR0.57 (0.42to0.76) 376per1000 214per1000 (158to286) Rate of intravenous rehydration up to 72 hrs followingdischargefrom ED (worst - best scenario) Mediumriskpopulation Ondansetron increases the chance of cessation ofvomiting ⊕⊕⊕○ moderate1 465 (3studies) Studypopulation RR1.33 (1.19to1.49) 639per1000 853per1000 (760to952) Proportion of patients with cessation of vomiting The medication does not reducetherevisitrate ⊕⊕○○ low1,2 460 (3studies) Revisitrate Studypopulation RR1.09 (0.66to1.79) 104per1000 113per1000 (69to186) Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Diarrheawas reportedas a side effect in all the studies Adverseevents Studypopulation Notestimable 465 (3studies) Seecomment Seecomment *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumedriskinthecomparisongroupandtherelativeeffectoftheintervention(andits95%CI). CI:confidenceinterval;RR:riskratio. 4
GRADEWorkingGroupgradesofevidence. Highquality:furtherresearchisveryunlikelytochangeourconfidenceintheestimateofeffect. Moderatequality:furtherresearchislikelytohaveanimportantimpactonourconfidenceintheestimateofeffectandmaychangetheestimate. Lowquality:furtherresearchisverylikelytohaveanimportantimpactonourconfidenceintheestimateofeffectandislikelytochangetheestimate. Verylowquality:weareveryuncertainabouttheestimate. 1 Designlimitation(riskofbias) 2 Inconsistencyduetopossiblechangeofeffectofinterventionovertimeandinconsistentfollowup xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 5
Page 1 and 2: Antiemetics for reducing vomiting r
Page 3 and 4: [Intervention Review] Antiemetics f
Page 5: S U M M A R Y O F F I N D I N G S F
Page 9 and 10: Why it is important to do this revi
Page 11 and 12: confidence intervals (CI) and P val
Page 13 and 14: Figure 1. Study flow diagram (PRISM
Page 15 and 16: participants in Freedman 2006 and R
Page 17 and 18: Figure 3. Risk of bias summary: rev
Page 19 and 20: All of the studies with the excepti
Page 21 and 22: esults were similar and the conclus
Page 23 and 24: Primary outcomes Time taken from th
Page 25 and 26: D I S C U S S I O N Overall complet
Page 27 and 28: severity of disease; and on outcome
Page 29 and 30: and Adolescent Medicine 2003;157(5)
Page 31 and 32: Cubeddu 1997 (Continued) Risk of bi
Page 33 and 34: Freedman 2006 (Continued) dependent
Page 35 and 36: Ramsook 2002 (Continued) Bias Autho
Page 37 and 38: Roslund 2008 (Continued) Notes Quot
Page 39 and 40: Stork 2006 (Continued) REHYDRATION
Page 41 and 42: Uhlig 2009 (Continued) Intervention
Page 43 and 44: Yilmaz 2010 (Continued) • Nonbili
Page 45 and 46: Yilmaz 2010 (Continued) Other bias
Page 47 and 48: NCT01165866 (Continued) Participant
Page 49 and 50: D A T A A N D A N A L Y S E S Compa
Page 51 and 52: Analysis 1.2. Comparison 1 Oral ond
Page 57 and 58:
Analysis 1.8. Comparison 1 Oral ond
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Table 5. Random-effects sensitivity
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Table 15. Parental satisfaction/imp
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A P P E N D I C E S Appendix 1. Sea
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Appendix 3. CENTRAL search strategy
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48. exp child/ or child$.tw. 49. ex
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or hexadecadrol or hexadrol or loka
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51. (promethazine or Avomine or adg
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W H A T ’ S N E W Last assessed a
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S O U R C E S O F S U P P O R T Int
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