Antiemetics for reducing vomiting related to acute ... - Update Software

More documents

Recommendations

Info

$Propofol versus thiopental sodium for the treatment of refractory ...$

Analysis 1.7. Comparison 1 Oral ondansetron (weight dependent dose) vs placebo, Outcome 7 Proportion of participants with cessation of vomiting. Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents Comparison: 1 Oral ondansetron (weight dependent dose) vs placebo Outcome: 7 Proportion of participants with cessation of vomiting Study or subgroup Ondansetron Placebo Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Freedman 2006 92/107 70/107 47.1 % 1.31 [ 1.12, 1.54 ] Ramsook 2002 64/74 46/71 31.6 % 1.33 [ 1.10, 1.62 ] Roslund 2008 42/51 33/55 21.4 % 1.37 [ 1.07, 1.76 ] Total (95% CI) 232 233 100.0 % 1.33 [ 1.19, 1.49 ] Total events: 198 (Ondansetron), 149 (Placebo) Heterogeneity: Chi 2 = 0.08, df = 2 (P = 0.96); I 2 =0.0% Test for overall effect: Z = 5.12 (P < 0.00001) Test for subgroup differences: Not applicable 0.5 0.7 1 1.5 2 Favours placebo Favours ondansetron Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 54
Analysis 1.8. Comparison 1 Oral ondansetron (weight dependent dose) vs placebo, Outcome 8 Revisit rate. Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents Comparison: 1 Oral ondansetron (weight dependent dose) vs placebo Outcome: 8 Revisit rate Study or subgroup Ondansetron Placebo Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Freedman 2006 20/105 22/101 90.2 % 0.87 [ 0.51, 1.50 ] Ramsook 2002 4/74 0/71 2.1 % 8.64 [ 0.47, 157.62 ] Roslund 2008 3/51 2/55 7.7 % 1.62 [ 0.28, 9.29 ] Total (95% CI) 230 227 100.0 % 1.09 [ 0.66, 1.79 ] Total events: 27 (Ondansetron), 24 (Placebo) Heterogeneity: Chi 2 = 2.79, df = 2 (P = 0.25); I 2 =28% Test for overall effect: Z = 0.35 (P = 0.73) Test for subgroup differences: Not applicable A D D I T I O N A L T A B L E S 0.01 0.1 1 10 100 Favours ondansetron Favours placebo Table 1. Admission, IV rehydration, and revisit rates (Freedman 2006) Ondansetron Placebo Admission rate (during ED stay) 4/107 5/107 Admission rate (Day 3) 10/107 11/103 IV rehydration rate (during ED stay) 15/107 33/107 IV rehydration (Day 3) 26/107 39/103 Revisit rate 20/105 22/101 Table 2. Admission, IV rehydration, and revisit rates (Ramsook 2002) Ondansetron Placebo Admission rate (during ED stay) 2/74 11/71 Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents (Review) Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 55
Page 1 and 2:
Antiemetics for reducing vomiting r
Page 3 and 4:
[Intervention Review] Antiemetics f
Page 5 and 6: S U M M A R Y O F F I N D I N G S F
Page 7 and 8: GRADEWorkingGroupgradesofevidence.
Page 9 and 10: Why it is important to do this revi
Page 11 and 12: confidence intervals (CI) and P val
Page 13 and 14: Figure 1. Study flow diagram (PRISM
Page 15 and 16: participants in Freedman 2006 and R
Page 17 and 18: Figure 3. Risk of bias summary: rev
Page 19 and 20: All of the studies with the excepti
Page 21 and 22: esults were similar and the conclus
Page 23 and 24: Primary outcomes Time taken from th
Page 25 and 26: D I S C U S S I O N Overall complet
Page 27 and 28: severity of disease; and on outcome
Page 29 and 30: and Adolescent Medicine 2003;157(5)
Page 31 and 32: Cubeddu 1997 (Continued) Risk of bi
Page 33 and 34: Freedman 2006 (Continued) dependent
Page 35 and 36: Ramsook 2002 (Continued) Bias Autho
Page 37 and 38: Roslund 2008 (Continued) Notes Quot
Page 39 and 40: Stork 2006 (Continued) REHYDRATION
Page 41 and 42: Uhlig 2009 (Continued) Intervention
Page 43 and 44: Yilmaz 2010 (Continued) • Nonbili
Page 45 and 46: Yilmaz 2010 (Continued) Other bias
Page 47 and 48: NCT01165866 (Continued) Participant
Page 49 and 50: D A T A A N D A N A L Y S E S Compa
Page 51 and 52: Analysis 1.2. Comparison 1 Oral ond
Page 53 and 54: Analysis 1.4. Comparison 1 Oral ond
Page 55: Analysis 1.6. Comparison 1 Oral ond
Page 59 and 60: Table 5. Random-effects sensitivity
Page 61 and 62: Table 15. Parental satisfaction/imp
Page 63 and 64: A P P E N D I C E S Appendix 1. Sea
Page 65 and 66: Appendix 3. CENTRAL search strategy
Page 67 and 68: 48. exp child/ or child$.tw. 49. ex
Page 69 and 70: or hexadecadrol or hexadrol or loka
Page 71 and 72: 51. (promethazine or Avomine or adg
Page 73 and 74: W H A T ’ S N E W Last assessed a
Page 75 and 76: S O U R C E S O F S U P P O R T Int
show all

Antiemetics for reducing vomiting related to acute ... - Update Software

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?