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144<br />
Determination of mic<strong>ro</strong>albuminuria was made<br />
also at 6 months after treatment start and we observed<br />
a remarkable d<strong>ro</strong>p in the patients treated<br />
with ACEi (30%) compared to those treated with<br />
other classes of antihypertensive drugs, so the regulation<br />
of lowering blood pressure drugs depends of<br />
the levels of mic<strong>ro</strong>albuminuria – also it can be consider<br />
as a ba<strong>ro</strong>meter for the adjustment of the doses<br />
of antihypertensive <st<strong>ro</strong>ng>medica</st<strong>ro</strong>ng>tion.<br />
Age at menarche is associated with diabetes<br />
in women (aged 23-81 years)<br />
Daniela Lica<strong>ro</strong>iu, Ana Maria Ionescu,<br />
Elena Caceaune, Nicu Caceaune, Andrada Doina<br />
Mihai, Alexandra Costache, Razvan Costache,<br />
Simona Carniciu, Constanti n Ionescu-Tirgoviste<br />
NIDNMD “N.C. Paulescu”, Bucharest, Romania<br />
Aims<br />
To examine the association between age at menarche<br />
and diabetes.<br />
Methods<br />
We analyzed 326 women aged 23-81 year, newly<br />
diagnosed with T2DM evaluated in a diabetic<br />
outpatient clinic (Diabetic Center N.C. Paulescu,<br />
Bucharest, Romania). Parameters analyzed were:<br />
age, age at menarche, BMI (kg/m2), waist circumference,<br />
FBG, total choleste<strong>ro</strong>l, HbA1c, insulinemia,<br />
HDL choleste<strong>ro</strong>l, triglycerides. We used<br />
Spearman‘s rho and Pearson correlation SPSS.15.0<br />
with p statistical signifi cant ≤0.05.<br />
Results<br />
A number of 77 women have the menarche before<br />
aged 12, and the rest (249) had the menarche<br />
after age 12. We further analyzed in these 2 g<strong>ro</strong>ups<br />
the correlation with plasma insulin, BMI, FBG<br />
(fasting blood glucose), HbA1C, total choleste<strong>ro</strong>l,<br />
HDLc. The mean age (years) for the 2 g<strong>ro</strong>ups (for<br />
female with menarche before 12 years old and after<br />
12 years old) was: 11.53/14.4. The differences between<br />
the g<strong>ro</strong>ups were: BMI 3<st<strong>ro</strong>ng>3.</st<strong>ro</strong>ng>17/32.06, HbA1C<br />
– 16.65/15.04, TC – 211.09/221, HDLc- 51.55/50.06,<br />
TG- 175.66/162. The main results are presented in<br />
table.<br />
Correlations<br />
Before 12 years Aft er >12 years<br />
Caracteristi cs Mean Mean<br />
Age (yrs) 57.18 (±11.50) 60.64 (±10.21)<br />
Menarcha (yrs) 11.53 (±.6.88) 14.40 (±2.38)<br />
REVISTA MEDICALÅ ROMÂNÅ – VOLUMUL LIX, NR. 2, An 2012<br />
Before 12 years Aft er >12 years<br />
Caracteristi cs Mean Mean<br />
BMI (kg/m2) 3<st<strong>ro</strong>ng>3.</st<strong>ro</strong>ng>17 (±6.98) 32.06 (±6.44)<br />
FBG (mg/dl) 186.79 (±88.34) 170.44 (±8<st<strong>ro</strong>ng>3.</st<strong>ro</strong>ng>63)<br />
HbA1c (%) 16.65 (±38.11) 15.04 (±37.70)<br />
Insulinemia (uU/ml) 19.96 (±16.86) 18.49 (±1<st<strong>ro</strong>ng>3.</st<strong>ro</strong>ng>43)<br />
Total Choleste<strong>ro</strong>l (mg/dl) 211.09 (±54.95) 221.00 (±56.09)<br />
HDLc (mg/dl) 51.55 (±26.12) 50.06 (±19.34)<br />
TG (mg/dl) 175.66 (±138.5) 162.48 (±110.85)<br />
Conclusions<br />
Age at menarche is an indicator of maturation<br />
and timing of puberty which could be related with<br />
some disturbances later during the life in girls and<br />
the younger aged at the menarche might lead to<br />
some ch<strong>ro</strong>nic diseases. In younger women we observed<br />
a decreased age at menarche occurrence. An<br />
earlier age at menarche seems to be related with<br />
obesity, higher values of HbA1c and triglycerides,<br />
and may be linked with the development of diabetes.<br />
In clinical practice we can apply this conclusion,<br />
by an earlier monitoring of this women g<strong>ro</strong>up<br />
to detect and monitoring diabetes onset.<br />
Morpho-functi onal parti culariti es<br />
of adipocyte in obese and<br />
type 2 diabetes pati ents<br />
Simona Carniciu 1 , Catalin Copaescu 2 ,<br />
Nicolae Mirancea 3 , Mihaela Ursache 2 ,<br />
Daniela Lixandru 4 , Daniela Lica<strong>ro</strong>iu 1 ,<br />
Constanti n Ionescu-Tirgoviste 1<br />
1 NIDNMD “N. C. Paulescu”, Bucharest<br />
2 Delta Hospital, Bucharest<br />
3 Insti tute of Biology of Romanian Academy, Bucharest<br />
4 “Ca<strong>ro</strong>l Davila” University of Medicine and Pharmacy,<br />
Bucharest<br />
It is known f<strong>ro</strong>m a long time that type 2 diabetes<br />
is closely associated with overweight/obesity. Recent<br />
advances in the knowledge of the biology of<br />
the adipose tissue raised the hope that the diabetogenic<br />
infl uences of overweight will be soon uncovered.<br />
For that a multidisciplinary team has been<br />
created in order to integrate the clinical, biochemical/biological<br />
and histological data obtained in<br />
obese type 2 diabetic patients versus nondiabetic<br />
obese subjects.<br />
Aims<br />
We intend to identify the relationship between<br />
morfo-functional particularities of adipocytes f<strong>ro</strong>m<br />
different adipose compartments in nondiabetic<br />
obese and in normal weight type 2 diabetics. Among
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