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Databases and Systems

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which minimizes dispersion. The optimization problem is linear <strong>and</strong> has a small<br />

number of variables, so it should be easily solvable.<br />

Map Integration<br />

y = 4.433*x + -177.1 ; r=0.97<br />

Figure 8: Direct minimization of dispersion<br />

Another approach to the query problem is to integrate the maps, <strong>and</strong> use coordinates<br />

in the integrated map as universal coordinates for querying purposes. What does<br />

integration mean? Don't the universal coordinate procedures described above<br />

perform a sort of integration, by placing all the elements of all the maps in a common<br />

framework? Yes <strong>and</strong> no. The universal coordinate approach can be viewed as<br />

producing a universal map which has one element for each map element in each of<br />

the source maps. A marker that appears in several maps will be associated with<br />

multiple map elements in such a universal map. An integrated map, by contrast,<br />

would put every marker in just one position, no mater how many primary maps it<br />

occurred in. That position should have an associated window of uncertainty, <strong>and</strong><br />

should be influenced by the marker's positions in the different source maps. The<br />

uncertainty should be truly reflective of the available information on the marker's<br />

position. Integration should ideally also eliminate the need to arbitrarily select one<br />

map as a st<strong>and</strong>ard, which introduces biases. The coordinates <strong>and</strong> uncertainties<br />

resulting from a meaningful integration along these lines might yield significantly<br />

improved query behavior over universal coordinates. See [4,5] for work in this area.<br />

Unfortunately, meangful integrated maps are considerably more difficult to construct<br />

than alignments; a key issue is how to combine order data from multiple maps <strong>and</strong><br />

preserve it in the integrated map. There are also a number of technical difficulties<br />

associated with defining a meaningful notion of an uncertainty window for a locus on<br />

an integrated map. Mapping uncertainty is normally associated with pairwise<br />

distances, yet for a map to be efficiently searchable it must use coordinates rather<br />

than intermarker distances. The st<strong>and</strong>ard error of a coordinate assignment as not a<br />

well defined concept, <strong>and</strong> yet some such notion is necessary to implement an<br />

appropriately fuzzy search. This is an important area for future work that affects the<br />

93

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