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Databases and Systems

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137<br />

This defines a viewing direction<strong>and</strong> corresponding rotation matrix R0 by<br />

cos( ) = n Iz<br />

<strong>and</strong> tan( ) =n1y / nIx <strong>and</strong> hence<br />

The new viewing angles are then given by cos( = nz <strong>and</strong> tan ( ) = ny/n x,<br />

<strong>and</strong> are parametrised by which ranges from 0 to 2 .<br />

The second means of navigation is to use fiducial points,i.e.points that have been<br />

previously defined <strong>and</strong> exist in the Atlas database for the purposes of navigation.<br />

Selecting a single point defines a rotation center, two points will define a line as<br />

above <strong>and</strong> a third will fully define a plane.<br />

Other navigational support is provided by a 3D feedback window (see figure 5) in<br />

which the section plane is displayed relative to the image bounding box <strong>and</strong> selected<br />

anatomical structures.<br />

Data Submission<br />

The Edinburgh Mouse Atlas has been developed primarily to support a geneexpression<br />

database by providing a spatial framework for the mapping expression<br />

<strong>and</strong> anatomical information. The methods for mapping spatially organized data onto<br />

the reconstructions can be categorized under the headings: text, painting or warping.<br />

Text submission:<br />

The spatial domain is described by listing anatomical components or existing<br />

database entries. Typically the user will define a domain by selecting anatomical<br />

components with the assumption the required domain is the union of the component<br />

domains (which by definition do not intersect). If in addition the user wishes to use<br />

predefined gene-expression domains these can be used to refine the new domain by<br />

using the set operations union, intersection <strong>and</strong> difference on the corresponding sets<br />

of voxel locations.

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