The report is available in English with a French summary - KCE

More documents

Recommendations

Info

28 Plasma KCE Reports 120 Human resources issues The nurses’ rate of activity is also a concern for the EFS: in practice, this rate is relatively low (in average around 55%), due to an inaccurate distribution of donation centres across the country and/or an inadequate organization of collection, especially considering the French sociological profile. In practice the use of donation rooms has not been rationalized yet, and the total amount of donor accommodation in donation rooms is often not fully used. Principles on cost rationalization Decision makers of the EFS have identified several key measures to improve cost efficiency of the donation system. All of these measures are not equally profitable for the donation system, but they all bring a helpful contribution to the smooth running of the whole process and to the best use of donated blood. The following measures listed below have been ranked from the most profitable to the less profitable (from a cost / efficiency point of view) considering today’s workforce. • Rationalizing the use of donation rooms and raising the nurses’ rate of activity: which involves a restructuring of donation facilities and a better distribution of donation. This will automatically raise the nurses’ rate of activity • Implementation of apherese with additive solution: this technique will improve individual rentability of blood donations • Unifying and raising the volume of individual donation Communication Campaigns: Further Information in Appendix “France : Plasma collection within the framework of EFS” Key points • The French system combines public law and private law rules in the field of collection, fractionation and supply. Plasma collection is not supported by public subsidies, and the sale price of plasma is fixed by the national health authorities. Delivery targets of the EFS will be raised gradually over the next years. • EFS’s communication policy targets students and young adults. • The main driver for the collection centres is to improve HR management, to increase individual collection volume, and to realize economies of scale.
KCE Reports 120 Plasma 29 2.2 TRANSFORMATION OF PLASMA INTO PLASMA DERIVATIVES 2.2.1 Quick overview of fractionation process Since the early 1940s the method of manufacturing plasma, initially developed by Pr Edwin J. Cohn, has been influenced by multiple factors, which over the years have forced the industry to adapt production in such a way that the optimal use of plasma – a human source - remains to be the leading objective. As already mentioned above, human plasma, is a unique biological material. Plasma fractionation, a “cracking” process (cf. petroleum “cracking”) used to prepare therapeutic proteins, is and remains a complex process. Human plasma derived protein products have unique characteristics linked to the origin of the starting raw material. Human plasma exhibits a complex biochemical nature due to its high protein content, close to 60 g per litre, and to the diversity of its protein components. Figure 4: Blood composition White cells & platelets 8% Red cells 42% Blood Plasma 50% Plasma Protein Other 7% 3% Water 90% Coagulation Factors 1% 1% Globulins 15% Protein Other 24% Albumin 60% Below is a list of the best-known of those proteins which are commercially available, although one should note that the order does not reflect the relative importance of the proteins. IVIG: Albumin intravenous immunoglobulin Factor VIII: coagulation factor Factor IX: coagulation factor AT-III: anti-thrombin III IMGG: intra-muscular gammaglobulin A1-AT: alpha-1 anti-trypsin Fibrin sealant IMGG anti-D: Up to 25 others intra-muscular gammaglobulin anti-Rh factor
Page 1 and 2: Comment assurer l’autosuffisance
Page 3 and 4: Comment assurer l’autosuffisance
Page 5 and 6: KCE Reports 120B Plasma i PRÉFACE
Page 7 and 8: KCE Reports 120B Plasma iii MÉTHOD
Page 9 and 10: KCE Reports 120B Plasma v En ce qui
Page 11 and 12: KCE Reports 120B Plasma vii RECOMMA
Page 13 and 14: KCE Reports 120 Plasma 1 Scientific
Page 15 and 16: KCE Reports 120 Plasma 3 GLOSSARY A
Page 17 and 18: KCE Reports 120 Plasma 5 1 INTRODUC
Page 19 and 20: KCE Reports 120 Plasma 7 Focus: sta
Page 21 and 22: KCE Reports 120 Plasma 9 Two techni
Page 23 and 24: KCE Reports 120 Plasma 11 Therefore
Page 25 and 26: KCE Reports 120 Plasma 13 FRENCH-SP
Page 27 and 28: KCE Reports 120 Plasma 15 Number of
Page 29 and 30: KCE Reports 120 Plasma 17 Table 4:
Page 35 and 36: KCE Reports 120 Plasma 23 Role of t
Page 37 and 38: KCE Reports 120 Plasma 25 2.1.3.2 P
Page 39: KCE Reports 120 Plasma 27 • 73% o
Page 43 and 44: KCE Reports 120 Plasma 31 Figure 6:
Page 45 and 46: KCE Reports 120 Plasma 33 GEOGRAPHI
Page 47 and 48: KCE Reports 120 Plasma 35 It is sur
Page 49 and 50: KCE Reports 120 Plasma 37 Plasma fr
Page 51 and 52: KCE Reports 120 Plasma 39 2.3 LIMIT
Page 55 and 56: KCE Reports 120 Plasma 43 3.2 INDIC
Page 57 and 58: KCE Reports 120 Plasma 45 Subcutane
Page 61 and 62: KCE Reports 120 Plasma 49 3.2.2 Evi
Page 63 and 64: KCE Reports 120 Plasma 51 Search re
Page 65 and 66: KCE Reports 120 Plasma 53 CIDP IG i
Page 67 and 68: KCE Reports 120 Plasma 55 • IG re
Page 69 and 70: KCE Reports 120 Plasma 57 Solid org
Page 71 and 72: KCE Reports 120 Plasma 59 A Cochran
Page 73 and 74: KCE Reports 120 Plasma 61 • In ch
Page 75 and 76: KCE Reports 120 Plasma 63 Two small
Page 77 and 78: KCE Reports 120 Plasma 65 was lower
Page 79 and 80: KCE Reports 120 Plasma 67 Three RCT
Page 81 and 82: KCE Reports 120 Plasma 69 Severe se
Page 83 and 84: KCE Reports 120 Plasma 71 The analy
Page 85 and 86: KCE Reports 120 Plasma 73 3.3.1.2 T
Page 87 and 88: KCE Reports 120 Plasma 75 Figure 7:
Page 89 and 90: KCE Reports 120 Plasma 77 Figure 10
Page 91 and 92:
KCE Reports 120 Plasma 79 Table 30:
Page 93 and 94:
KCE Reports 120 Plasma 81 Table 36:
Page 95 and 96:
KCE Reports 120 Plasma 83 • For b
Page 97 and 98:
KCE Reports 120 Plasma 85 3.3.2.6 L
Page 99 and 100:
KCE Reports 120 Plasma 87 • The p
Page 101 and 102:
KCE Reports 120 Plasma 89 In Belgiu
Page 103 and 104:
KCE Reports 120 Plasma 91 Multifoca
Page 105 and 106:
KCE Reports 120 Plasma 93 Based on
Page 107 and 108:
KCE Reports 120 Plasma 95 Disease /
Page 109 and 110:
KCE Reports 120 Plasma 97 3.3.4 Exp
Page 111 and 112:
KCE Reports 120 Plasma 99 Figure 12
Page 113 and 114:
KCE Reports 120 Plasma 101 Key poin
Page 115 and 116:
KCE Reports 120 Plasma 103 Key poin
Page 117 and 118:
KCE Reports 120 Plasma 105 • Conf
Page 119 and 120:
KCE Reports 120 Plasma 107 As far a
Page 121 and 122:
KCE Reports 120 Plasma 109 Followin
Page 123 and 124:
KCE Reports 120 Plasma 111 4.3 HOW
Page 125 and 126:
KCE Reports 120 Plasma 113 Improvin
Page 127 and 128:
KCE Reports 120 Plasma 115 4.3.2 St
Page 129 and 130:
KCE Reports 120 Plasma 117 4.4 CONC
Page 131 and 132:
KCE Reports 120 Plasma 119 FAVOURIN
Page 133 and 134:
KCE Reports 120 Plasma 121 APPENDIX
Page 135 and 136:
KCE Reports 120 Plasma 123 For othe
Page 137 and 138:
KCE Reports 120 Plasma 125 Table 48
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
KCE Reports 120 Plasma 131 Distribu
Page 145 and 146:
KCE Reports 120 Plasma 133 • Conv
Page 147 and 148:
Page 149 and 150:
KCE Reports 120 Plasma 137 6 REFERE
Page 151 and 152:
KCE Reports 120 Plasma 139 41. Pruz
Page 153 and 154:
KCE Reports 120 Plasma 141 82. Comi
Page 155 and 156:
KCE Reports 120 Plasma 143 123. Cre
Page 157 and 158:
KCE Reports 120 Plasma 145 165. Cua
Page 159 and 160:
This page is left intentionally bla
Page 161 and 162:
KCE reports 1. Efficacité et renta
Page 163 and 164:
73. Financement du programme de soi
show all

The report is available in English with a French summary - KCE

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?