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Long-term Memory

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• Bilateral damage to the medial temporal lobes (including<br />

the hippocampus)<br />

– inability to make new memories<br />

• anterograde amnesia<br />

– some loss of old memories from just before the damage<br />

• retrograde amnesia<br />

– sources of damage<br />

• permanent: Surgery, stroke, hypoxia, head injury, encephalitis<br />

• progressive: Korsakoff’s syndrome, Alzheimer’s disease<br />

• temporary: electroconvulsive therapy (ECT), benzodiazepines<br />

• unilateral hippocampal damage<br />

– left = verbal memory<br />

– right = spatial memory<br />

• hippocampal versus parahippocampal damage<br />

– recall versus familiarity?<br />

brain<br />

damage<br />

PAST PRESENT<br />

retrograde<br />

anterograde

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