2009 Vienna - European Society of Human Genetics

Complex traits and polygenic disorders
lations suggested that the gene has undergone a selective sweep in
Europeans, in agreement with previous studies. Network analysis indicated
the presence of two haplotype clades, with SCZ-susceptibility
haplotypes clustering within the major clade.
P09.114
serotonin transporter gene sLc6A4 is associated with negative
affect intensity
F. Mathieu 1 , R. Raymond 1 , B. Etain 1,2 , S. Jamain 1 , C. Henry 1,2,3 , F. Bellivier 1,2,3 ,
M. Leboyer 1,2,3 ;
1 INSERMU955, Créteil, France, 2 AP-HP, Groupe Henri Mondor-Albert Chenevier,
Créteil, France, 3 Université Paris 12, Faculté de Médecine, Créteil, France.
Genetic analyses of bipolar disorder (BD) may be facilitated by the
use of intermediate phenotypes. We recently showed that euthymic
bipolar patients have higher affect intensity than controls (Henry et al.
2008). In the present study, we assessed the 40-items Affect Intensity
Measure (AIM) scale (Larsen and Diener, 1986) to 245 bipolar patients
and 92 control subjects. As the uni-dimensional structure of the AIM
scale has been often questionned, a factorial analysis was performed
in the two groups. A similar four factor structure was retained in both
samples of bipolar patients and controls: positive affectivity, serenity,
negative intensity and negative reactivity. The four dimensions were
higher in bipolar patients than in controls (p