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CHAPTER 2 MOUSE MODELS TO STUDY THE CONSEQUENCES OF DEFECTIVE NUCLEOTIDE EXCISION REPAIR.
Page 1 and 2: A MOUSE MODEL FOR TRICHOTHIODYSTROP
Page 3 and 4: CONTENTS Aim of the thesis 5 Chapte
Page 5: AIM OF THE THESIS Nucleotide excisi
Page 9 and 10: NUCLEOTIDE EXCISION REPAIR AND HUMA
Page 11 and 12: capacity to generate bulky base add
Page 14 and 15: strong interaction between XPG and
Page 16 and 17: XP is characterized by genetic hete
Page 18: are diagnosed as a collodion baby (
Page 22 and 23: 23. Gerard, M., Fischer, L., Moncol
Page 24 and 25: associatcd with mutations in the DN
Page 29 and 30: MOUSE MODELS TO STUDY THE CONSEQUEN
Page 33 and 34: UV-INDUCED SKIN CANCER AND MUTAGENE
Page 35 and 36: Thus, in an experimental setup wher
Page 37 and 38: section, the phenotype of several o
Page 39: of the detoxification proteins meta
Page 42 and 43: Future research should unravel whet
Page 46 and 47: 35. Smith, J.R., Pereira-Smith, O.M
Page 49 and 50: DISRUPTION OF THE MOUSE XPD DNA REP
Page 55: Table I. Genotype analysis of XPD e
Page 62 and 63: 29. Srneets, 11., Bacilinski, L., C
Page 69: associated with defects inXPD. As r
Page 73: of hair of TTD mice (of both first
Page 79:
The TTD mouse and inborn defects in
Page 82:
440 11m. The amount of each amino a
Page 85:
CHAPTER 5 MOUSE MODEL FOR THE DNA R
Page 89:
patients have a reduced life expect
Page 95 and 96:
using a similar protocol, XPA-defic
Page 97 and 98:
mouse and man, e.g. in metabolic ra
Page 99:
fraction (TNO-voeding Zeist) was ad
Page 102 and 103:
35, Vcnema,.I., L. H. F. Mullenders
Page 105 and 106:
SYMPTOMS OF PREMATURE AGING IN A MO
Page 107 and 108:
DNA repair and transcription are al
Page 109 and 110:
Ovarian dysfunction Although sexual
Page 113 and 114:
Table 1. Blood cell values of wild-
Page 115 and 116:
cells involved in bone homeostasis
Page 117 and 118:
EXPERIMENTAL PROCEDURES Mice The ge
Page 120 and 121:
43. de Vries, A" vun Ooslrol11, C.T
Page 122 and 123:
CARCINOGENESIS Previously, the NER
Page 124 and 125:
AGING The complex process of aging
Page 129 and 130:
typische TTD symptomen als breekbar
Page 131 and 132:
Naam Geboren juni 1987 juni 1988 se
Page 133 and 134:
de Boer, J., and Hocijmakers, UU. (
Page 135:
Rotterdanuller met een auto vol kal
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