View PDF Version - RePub - Erasmus Universiteit Rotterdam
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Table I. Genotype analysis of XPD emblYos and progeny<br />
Cross Genotype<br />
Male Female<br />
Age of Number of<br />
progeny pups per litter<br />
+/+ +/- -/-<br />
(+1-) X (+1-) Newborn 6.4 23 63 0<br />
(+1-) x (+1+) Newbom 6.5 50 54<br />
(+1-) x (+1-) E7.5 8 19 0<br />
" Both embryos and neonates were genotyped by peR analysis as described in "Materials and<br />
Methods"<br />
analyzed, 63 (31 %) where arrested in the two-cell stage. In parallel experiments,<br />
control embryos were isolated from matings between heterozygous XPD males and<br />
wild-type females. From 244 embryos examined, 32 (13%) were anested in the 2cell<br />
stage (Table 2). Statistical analysis shows a significant difference between the<br />
two relative values in a student's T test (p
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