- Page 1 and 2: A MOUSE MODEL FOR TRICHOTHIODYSTROP
- Page 3 and 4: CONTENTS Aim of the thesis 5 Chapte
- Page 5: AIM OF THE THESIS Nucleotide excisi
- Page 10 and 11: a more detailed overview on the bio
- Page 12: Lesioll demarcatioll The next step
- Page 15 and 16: NUCLEOTIDE EXCISION REPAIR DEFICIEN
- Page 17 and 18: mice display only mild CS symptoms,
- Page 21 and 22: REFERENCES 1, Kripkc, M.L. and Aust
- Page 23 and 24: encodes a WD repeat protein that in
- Page 25: 7(,. Madzak, c., Armicr, J., Stmy,
- Page 29 and 30: MOUSE MODELS TO STUDY THE CONSEQUEN
- Page 33 and 34: UV-INDUCED SKIN CANCER AND MUTAGENE
- Page 35 and 36: Thus, in an experimental setup wher
- Page 37 and 38: section, the phenotype of several o
- Page 39: of the detoxification proteins meta
- Page 42 and 43: Future research should unravel whet
- Page 46 and 47: 35. Smith, J.R., Pereira-Smith, O.M
- Page 49 and 50: DISRUPTION OF THE MOUSE XPD DNA REP
- Page 55: Table I. Genotype analysis of XPD e
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29. Srneets, 11., Bacilinski, L., C
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associated with defects inXPD. As r
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of hair of TTD mice (of both first
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The TTD mouse and inborn defects in
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440 11m. The amount of each amino a
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CHAPTER 5 MOUSE MODEL FOR THE DNA R
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patients have a reduced life expect
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using a similar protocol, XPA-defic
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mouse and man, e.g. in metabolic ra
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fraction (TNO-voeding Zeist) was ad
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35, Vcnema,.I., L. H. F. Mullenders
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SYMPTOMS OF PREMATURE AGING IN A MO
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DNA repair and transcription are al
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Ovarian dysfunction Although sexual
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Table 1. Blood cell values of wild-
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cells involved in bone homeostasis
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EXPERIMENTAL PROCEDURES Mice The ge
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43. de Vries, A" vun Ooslrol11, C.T
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CARCINOGENESIS Previously, the NER
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AGING The complex process of aging
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typische TTD symptomen als breekbar
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Naam Geboren juni 1987 juni 1988 se
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de Boer, J., and Hocijmakers, UU. (
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Rotterdanuller met een auto vol kal