- Page 1 and 2: A MOUSE MODEL FOR TRICHOTHIODYSTROP
- Page 3: CONTENTS Aim of the thesis 5 Chapte
- Page 9 and 10: NUCLEOTIDE EXCISION REPAIR AND HUMA
- Page 11 and 12: capacity to generate bulky base add
- Page 14 and 15: strong interaction between XPG and
- Page 16 and 17: XP is characterized by genetic hete
- Page 18: are diagnosed as a collodion baby (
- Page 22 and 23: 23. Gerard, M., Fischer, L., Moncol
- Page 24 and 25: associatcd with mutations in the DN
- Page 27: CHAPTER 2 MOUSE MODELS TO STUDY THE
- Page 30: NER DEFICIENCY AND GENOTOXIC SENSIT
- Page 34 and 35: XPC-I-p53+1- mice were more aggress
- Page 36 and 37: tumor development was absent in a g
- Page 38 and 39: [8, 9] reported substantial embryon
- Page 41 and 42: in male sterility. As suggested by
- Page 43: A point of concern in the extrapola
- Page 47: CHAPTER 3 DISRUPTION OF THE MOUSE X
- Page 50: INTRODUCTION To counteract the dele
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RAD3 and RAD25 protein (the latter
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CHAPTER 4 A MOUSE MODEL FOR THE BAS
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Death occurs after a short period o
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Table 3. Comparison of the TTDIBEL
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model (UDS, UV survival, pathology,
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33. Stefanini, M., Giliani, S., Nar
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INTRODUCTION Genomic instability is
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correlates very well with literatur
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mice, which are histologically noml
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proneness in mice cOlTesponds with
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18, Lehmann, A. R., C. F, Arlclt, B
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CHAPTER 6 SYMPTOMS OF PREMATURE AGI
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INTRODUCTION The genome is under co
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osteosclerosis, carly depigmentatio
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oocyte that showed gemlinal vesicle
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DISCUSSION Human aging syndromes Ag
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lower levels of the anti-oxidants s
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6. Nance, M.A and Ben·y, S.A. (199
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SUMMARY AND CONCLUSIONS DNA damage
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features are due to an impairment o
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symptoms in normal aging. Oxidative
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In Hoofdstuk 5 worden experimenten
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LIST OF PUBLICATIONS Bitter, W., va
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DANKWOORD Het schrijven van een dan