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Guidelines for Metals and Metalloids in Ambient ... - ARCHIVE: Defra

Guidelines for Metals and Metalloids in Ambient ... - ARCHIVE: Defra

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Glossary<br />

Threshold Limit<br />

Values (TLVs)<br />

Toxicological<br />

Toxicok<strong>in</strong>etics<br />

Transferr<strong>in</strong><br />

Vasospastic symptoms<br />

These values are established by the American<br />

Conference of Governmental Industrial<br />

Hygienists (ACGIH). They are the concentration<br />

<strong>in</strong> air of a substance to which, it is believed that,<br />

most workers can be exposed daily without<br />

adverse effect. Quoted as time weighted<br />

concentrations <strong>for</strong> a seven or eight hour workday<br />

<strong>and</strong> a 40 hour work<strong>in</strong>g week. For most substances<br />

the value may be exceeded, to a certa<strong>in</strong> extent,<br />

provided there are compensat<strong>in</strong>g periods of<br />

exposure below the value dur<strong>in</strong>g the workday or,<br />

<strong>in</strong> some cases, work<strong>in</strong>g week. A limited number of<br />

substances are given ceil<strong>in</strong>g concentrations that<br />

should never be exceeded.<br />

Relat<strong>in</strong>g to toxicology, ie, the nature <strong>and</strong> effects<br />

of poisons.<br />

Application of pharmacok<strong>in</strong>etics to determ<strong>in</strong>e the<br />

relationship between the systemic exposure of a<br />

compound <strong>in</strong> experimental animals <strong>and</strong> its<br />

toxicity. It is used primarily <strong>for</strong> establish<strong>in</strong>g<br />

relationships between exposures <strong>in</strong> toxicology<br />

experiments <strong>in</strong> animals <strong>and</strong> the correspond<strong>in</strong>g<br />

exposures <strong>in</strong> humans.<br />

Any of several beta globul<strong>in</strong>s found <strong>in</strong> blood<br />

serum which b<strong>in</strong>d <strong>and</strong> transport iron.<br />

Sudden constriction of a blood vessel, result<strong>in</strong>g <strong>in</strong><br />

reduced flow.<br />

115

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