il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

The RAR o and PPAR-õ receptors RNA levels were measured in the hearts of ADR'
ADR+PROB and coNT group animals (Fig.15). Adriamycin in the ADR group caused a 58o/o
increase in the signal for RAR-a isoform I when compared to CONT. Probucol treatment in the
ADR+PROB group did not modiff this effect. The same group exhibited a 2Io/o increase in the
PPAR õ and a L6 Yo ncrease in PPAR y receptor levels and' again, probucol had no effect on
these adriamycin induced changes. Adriamycin caused a 56/o decrease in the cellular retinol
binding protein (CRBP) signal whereas the addition of probucol in the ADR+PROB group not
only prevent this change butthe sigpal for CRBP was in fact increasedby 55% (Fig' 15)'
^30%
decrease in the cellular retinoic acid binding protein type tr (CRABP II) was seen in the ADR
group. concomitant treatment with antioxidant drug probucol, in the ADR+PROB group hearts,
restored the CRABP II signal. These d¿ta are an avaÍa+e of only two experiments and the
information can, therefore, be viewed only as suggestive'
90