il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

IIh.4.RXR ølpha receotor levels
The administration of 4, I and l0 UM concentrations of adriamycin to ADR group
myocytes resulted in the 34Yo, 37yo and 77To decrease in the RXR alpha levels
respectively (Fig. 22).Trolox administration not only blunted this effect of adriamycin,
but in case of 10 pM adriamycin it actually increased the RXR alpha by 150% $ig.22).
0.1 pM retinoic acid administration to the same group caused 269% increase, while at 8
pM adriamycin, the effect was 50olo increase and at 10 ttM of adriamycin there was no
change in the RXR alpha expression when compared to CONT. lUM retinoic acid
treatment of 4 and S UJvl adriamycin treated myocytes resulted in 13 % and 25To
decrease in the RXR atpha expression. At l0 pM adriamycin there was a 175% increase
in RXR alpha expression in the presence of 1 UM retinoic acid.
104