il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...
il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...
il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...
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ILb. 5. RXR baa recEúor levels<br />
The administr<strong>at</strong>ion <strong>of</strong> 8 and 10 UM <strong>of</strong> adriamycin to ADR tre<strong>at</strong>ed cells caused<br />
I03% and 147Yo increase in <strong>the</strong> expression <strong>of</strong> RXR beta (Fig. 23), while 4 pM<br />
adriamycin had no effect on <strong>the</strong> expression <strong>of</strong> this receptor. The administr<strong>at</strong>ion <strong>of</strong> trolox<br />
to adriamycin tre<strong>at</strong>ed cells caused a significant increase in RXR beta levels <strong>at</strong> all<br />
concentr<strong>at</strong>ions <strong>of</strong> adriamycin (Fig. 23). The tre<strong>at</strong>ment with 0.1pM retinoic acid caused<br />
75yo,70 Yo and 500á decrease in <strong>the</strong> RXR beta expression <strong>at</strong> 4, 8 and 10 pM adriamycin<br />
respectively (Fig 23). Tre<strong>at</strong>ment with l¡rlVf retinoic acid resulted in significant increase<br />
in <strong>the</strong> RXRbeta receptor levels <strong>at</strong> 8 and l0 pM adriamycin administr<strong>at</strong>ion (Fig. 23).<br />
106
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