il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

ILb. 3. RAR sammø recEtor levels
From the three concentrations used, the administration of I pM of adriamycin
caused a 49Yo decrease in the expression of RAR gaÍlma receptors in the ADR goup
myocytes (Fig. 21). The administration of trolox to 4 pM adriamycin treated cells
resulted in a significant decrease (33%) in the expression of RAR gamma, while I and l0
¡rM adriamycin caused a small but significant increase in the expression of RAR y (Fig.
21). Treatment with 0.1 pM retinoic acid at atl three concentrations of adriamycin caused
a significant decrease, while ADR+I RA group myocytes treated with 8 and 10 ¡rM of
adriamycin showed a decrease in the RAR gamma receptor levels (Fig. 21).
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