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160 R a d i u m If we review our results we can state that in comparison with the values found by Werner, about 70% of the cases (Werner 55?&) were influenced, while 30^ (Werner 45%) did not give any results even with treatment with very high doses. We do not. however, want to say that only very high doses, as mentioned before, have an effect. Against this speak the good experiences which we have had with others when treating with average or small doses. According to Strasburger, the number and degree of success did not increase in arithmetical proportion with the strength of the doses, but as he thinks in nuich smaller progression. However, where small doses did not give any result, treatments with higher doses should be given. Our observations show that diseases of the joints, which have been treated with doses that according to our present opinion are high, show only small results can be successfully influenced by flooding the <strong>org</strong>anism of the body with radium emanation by further increase of the doses up to 1.000,000 M. XJ. and more. Harvey R. Gaylord, M. D. OBITCARY Dr. Harvey R. Gaylord. Director of the State Institute for The Study of Malignant Disease, at Buffalo, X. V., died at Watkin's Glen, June 22nd. Dr. Gaylord was born in Saginaw, Michigan, in 1872, and was graduated in medicine from the University of Pennsylvania in 1893. He served as an instructor in pathology for three years at the University of Goettingen, and began his service with the Xew York State Institute at Buffalo as an assistant to the late Dr. Roswcll Park. In 1914 Dr. Gaylord secured a quantity of radium in order that he might study its use in the treatment of cancer. Later he was instrumental in having the State purchase two and a quarter grams of radium for use at the State Institute in the treatment of indigent cancer patients from Xew York State, and as far as this quantity permitted, from other States. Dr. Gaylord and his associates have also made intensive and careful studies in the use of massive doses of short wave length x-rays in the treatment of cancer. Dr. Gaylord's keen and energetic personality was a great factor in the successful conduct of the State Institute under his direction, and in his passing the State of New York has lost a faithful and valuable servant, and Radiotherapy will mourn for one who has done much to advance this science.
A QUARTERLY JOURNAL DEVOTED TO THE CHEMISTRY. PHYSICS AND THERAPEUTICS OF RADIUM AND RADIO-ACTIVE SUBSTANCES Copyright 1924 by Radium Chemical Co. Edited by Charles H. Viol, Ph. D., and William H. Cameron. M. D.. with the assist collaborators working in the fieldsof Radiochemistry, Radioactivity and Radiumtherapy. Address all communications to the Editors. Forbes and Meyran Avenues. Pittsburgh, Pa. Annual Subscription $2.00. Single Copies 50 Cents. VOL. 3, New Series OCTOBER, 1924 No. 3 THE TREATMENT OF MALIGNANT DISEASES WITH RADIUM AND X-RAY-CANCER OF THE CERVIX* By RoBiiki B. Gbfenougii, M. D., F. A. C. S., Boston, Chairman Report of Ihe Committee ol Mallgnani Diseases with Radium and X-ray, appointed by the American College ot Surgeon* The result of treatment of cancer of the cervix of the uterus was selected as the first subject for investigation. Abstract cards were prepared by the committee and the co-operation of the established clinics in the various cities represented was sought and obtained. To the many individuals who have taken part in the investigation, and especially to those junior men who look on the laborious task of transferring the clinic records to the abstract cards, the thanks of the committee are due. Without their interest and cooperation the investigation would have been impossible. The cases selected for study were all treated in the years 1914 to 1919 inclusive. Each clinic was requested to provide a record of the cases of cancer of the cervix which entered the hospital within that •Reprinted by permission from Surgery. Gynecology and Obstetrics. BXU, 18-2G. July. 1924. The accompanying report Is that of a conuniltee appointed In February, 1932. and Includes the data collected up to February 1. 1924. The membership of the commltlee Is as" follows: C. F. Buraam, Baltimore; G. W. Crlle, Cleveland: William Dunne, Boston; J, SI. T. Finney. Baltimore: Burlon J. Lee, New York; H. K. Pancoast. Philadelphia; H. Gideon Wells. Chicago: Francis C. Wood, New York; R. B. Greennugti. chairman. Boston. The chairmen of the local committees are: J. M. T. Finney. Baltimore; R. B. Grcenough, Boston; Harrey R. Gaylord, Buffalo; Albert J. Ochaner, Chicago: Ge<strong>org</strong>e W. Crlle. Cleveland: C. Jen* Miller. New Orleans; Charles H. Peck, New York; John G. Clark, Philadelphia; Charles H. Mayo, Rochester; Aleiander Primrose. Toronto.
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PRESENTED BY PUBLISHER
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CONTENTS OF VOLUME THREE. NEW SERIE
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F. W. Aston, D.Sc, F.R.S. Atoms and
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2 Radium P. M. the apparatus is app
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Radium value of the metal container
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Radium Table I—Continued Classifi
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8 RADIUM The affections of the thyr
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10 R a d i u m The treatment should
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12 Rapitjm ooo per cubic millimetre
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14 Radium tines of tubercle bacilli
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16 R A D I U M 4. Lymphatic Leukaem
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18 RADIUM than in anv other organs
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20 R a d i u m In a previous paper
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99 Radium 2 mm. thick; the whole ap
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2-1 Radium inum tubes in use. These
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26 R a d i u m 5-gr. capsule and sw
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28 R A D I U M 1 tared, as in the f
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80 R a d i u m (6) The greatly less
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32 R a d i u m and at times three,
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04 R a d i u m capsule is placed un
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36 R a d i u m 1 have observed one
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38 R A D I U M Frequency and Distri
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10 R a d i u m holder with comparat
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42 HADITJ M gestion of the eve whic
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44 R a d i u m The low polymorphonu
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46 Radium examined, it is believed
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48 I^ADITJM Positive results of exp
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50 R a d i u m 1 Is e III , -m If "
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»2 R a d i u m The summary of phys
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Radium 55
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R a d i u m 57 s V. — •7 CO N
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R a d i u m 59 Measuring radium by
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R a d i u m 6i Bibliography I. Gudz
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R a d i u m 68 Ited cells, SUBJECT
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R a d i u m TECHNIQUE OF RADIUM TRE
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R a d i u m B7 INDEX OF ARTICLES RE
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R a d i u m 69 Bower, J. O. and Cla
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R a d i u m 71 —Treatment of mali
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R a d i u m 73 —Carcinoma of oeso
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R a d i u m 75 —Uses of radium in
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R a d i u m 77 Kimbrough. J. B. and
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R a d i u m 7^ Lymph Nodes—Histol
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R a d i u m si Nicolich—Carcinoma
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R a d i u m 83 Radium— —Large d
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a d i u m 85 -Physical conditions o
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R a d i u m ST Arch. f. Gynak. 118:
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R a d i u m 89 Scholten, G. C. J.
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R a d i u m 91 (A. J. Larkin) Am. J
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R a d i u m 93 —Xecessity for com
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RADIUM 95 Wallerstein, E. U.—X-ra
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A QUARTERLY JOURNAL DEVOTED TO THE
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R a d i u m 99 casionally a carcino
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R a d i u m 101 would be detected w
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R a d i u m 103 cially likely if th
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R A D I U M 105 radium irradiations
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R a d i u m 107 that in nearly ever
Page 117 and 118: R a d i u m 109 liver and lung meta
Page 119 and 120: Radium in Appleton Co., 1922. (2) P
Page 121 and 122: R a d i u m 113 BLOCKING LYMPHATICS
Page 123 and 124: R a d i u m 115 removed, and the ra
Page 125 and 126: R a d i u m in PATHOLOGY Pathologic
Page 127 and 128: 4. Cauhape: Thesis. Paris. 1911. R
Page 129 and 130: R a d i u m 121 is necessary by thi
Page 131 and 132: Radium 123 is injected into the tis
Page 133 and 134: R a d i u m 125 (3) Polonaise Numbe
Page 135 and 136: R a d i u m 127 modern laboratories
Page 137 and 138: R a d i u m 129 NINTH ANNUAL MEETIN
Page 139 and 140: R a d i u m 131 Several distinguish
Page 141 and 142: R a d i u m 133 which X-rays or rad
Page 143 and 144: R A D I U M 135 In the autobiograph
Page 145 and 146: R A D I U M 137 of radical operatio
Page 147 and 148: R a d i u m 139 reports 26 cases, 8
Page 149 and 150: R a d i u m 141 George W. Crile, M.
Page 151 and 152: R a d i u m 143 "In carcinoma of th
Page 153 and 154: R a d i u m 145 " 1 he principal ob
Page 155 and 156: IUM 147 have found no means of obvi
Page 157 and 158: R a d i u m 149 and six hours. Now
Page 159 and 160: R a d i u m 151 thoroughly transfix
Page 161 and 162: R a d i u m 153 weakness, palpitati
Page 163 and 164: R a d i u m 155 had all been benefi
Page 165 and 166: R a d i u m i57 tation of the kidne
Page 167: Radium 159 Can walk only with a can
Page 171 and 172: R a d i u m 163 in operative clinic
Page 173 and 174: a d i u m 165 In Table II we have d
Page 175 and 176: Hajmu.m 167 tery was used in combin
Page 177 and 178: R a d i u m 169 TABLE IX.—RESULTS
Page 179 and 180: R a d i u m m Radium alone Class i.
Page 181 and 182: R a d i u m 173 and papillary carci
Page 183 and 184: R a d i u m 175 It grows rapidly, i
Page 185 and 186: R a d i u m 177 emanation tubes. Th
Page 187 and 188: R a d i u m 179 never at any time f
Page 189 and 190: R a d i u m 181 THE TREATMENT OF MA
Page 191 and 192: R a d i u m 183 Cast 3. Carcinoma a
Page 193 and 194: R a d i u m 185 Chm 7. Showing cond
Page 195 and 196: R a d i u m 187 courting disaster b
Page 197 and 198: R a d i u m 189 radium in the treat
Page 199 and 200: R a d i u m 191 Histologic changes
Page 201 and 202: R a d i u m 193 about their involut
Page 203 and 204: R a d i u m 195 due to x-ray, sunli
Page 205 and 206: R a d i u m 197 zation of a partial
Page 207 and 208: R a d i u m 199 to report his cases
Page 209 and 210: 201 very often will result in a dec
Page 211 and 212: R a d i u m 203 the cautious use of
Page 213 and 214: IUM 205 On Jan. 14th. which was a v
Page 215 and 216: CONCLUSIONS 207 That in some cases
Page 217 and 218: R a d i u m 209 (b) The fluorescent
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R a d i u m •, 211 patient. The p
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R a d i u m 213 radiological depart
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R a d i u m 215 fortunately, the im
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R a d i u m 217 know whether such c
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R a d i u m 219 eight months had el
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R a d i u m 221 "The selective and
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R a d i u m 223 of a simple unitary
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A QUARTERLY JOURNAL DEVOTED TO THE
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R a d i u m 227 in their beta ray a
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R a d i u m 229 or the gradation of
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R a d i u m 231 be left in malignan
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R a d i u m 233 during repeated cau
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R a d i u m 235 3. The presence of
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R a d i u m 237 situated at the lim
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R a d i u m 239 REFERENCES 1. Wickh
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Rajpium 241 the test of five years,
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R a d i u m 243 comparative statist
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R a d i u m 245 end results of 201
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R a d i u m 247 Operation Hysterect
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R a d i u m 'IV.) and five years, a
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R a d i u m 251 or effect upon, the
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R a d i u m 253 2. Early Cases.—T
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R a d i u m 255 groups: the superfi
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R a d i u m 257 "I am becoming more
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R a d i u m 259 ment of 'Radiumhemm
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R a d i u m 261 unusual symptoms an
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R a d i u m 263 dition continued sa
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R a d i u m 265 died from hemorrhag
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R a d i u m 267 equals 132 millicur
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R a d i u m 269 "The data in the li
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R a d i u m 271 animals a diminutio
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R a d i u m 273 rays as contrasted
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R a d i u m 275 depression than a d
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R a d i u m 277 repeated operations
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R a d i u m 279 tonsil completely,
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Radium 281 Ihe tonsil is dangerous
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R a d i u m 283 WILLIAM H. B. AIKIN
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DEVOTED TO THE CHEMISTRY, PHYSICS A
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PUBLISHED SEMI-ANNUALLY AND DEVOTED
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R a d i u m 3 ORAL CANCER The next
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lymph nodes in even case, but when
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adiation up to 2400 milligram hours
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R a d i u m o radium to relieve pat
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R a d i u m 11 Uterine Fibroids The
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R a d i u m i3 by some operators. X
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R a d i u m 15 from the operation h
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R a d i u m n tions, the distance s
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R a d i u m 19 APPENDIX RADIUM AND
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Radium 21 BASIC AND CONTBIBUTING FA
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RA.PIUM 23 X-RAY AND RADIUM THERAPY
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R a d i u m 25 Since, by the impact
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R a d i u m 27 duccd which were cov
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R a d i u m 29 In other cases the g
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R a d i u m 31 The recital of this
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R a d i u m 33 index of articles re
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R a d i u m 35 Block, F. B., and Cl
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R a d i u m ?,- J. R. Ranson) Color
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R a d i u m :;:» —Epithelioma of
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R a d i u m 4I Forsdike. S.-Cancer
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R a d i u m 43 Hot Springs, Arkansa
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R a d i u m 45 Lee. B. J., and Here
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R a d i u m 47 Mineral Waters, exam
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R a d i u m 49 —Treatment of inop
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R a d i u m 51 - Metabolic changes
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R a d i u m 58 Radium, emanation—
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R a d i u m .>.) —Physiological a
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R a d i u m 57 —Experimental rese
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R a d i u m 59 Spleen, physiology
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R a d i u m 6l —Animal tumor cell
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R a d i u m es —Treatment of uter
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PUBLISHED SEMI-ANNUALLY AND DEVOTED
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R a d i u m e? CONTRAINDICATIONS TO
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R a d i u m 69 in addition to the i
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Radium 71 the most common, in the o
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R a d i u m ?:; nexae is a positive
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R a d i u m 76 essential to success
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R a d i u m 77 Our technique is to
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carcinoma of the CERVIX R a d i u m
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R a d i u m 81 a bleeding, cauliflo
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R a d i u m HS Fibrinous patch on e
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R a d i u m sr, mal 7 days later. A
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R a d i u m ST idly develops and me
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R a d i u m 89 2. Cervical cancer o
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R a d i u m 91 irradiation treatmen
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R a d i u m 93 by a study of curett
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R a d i u m 96 parenchyma eventuall
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R a d i u m 97 ihe lowest (2) was t
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R a d i u m 99 3. The treatment int
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R a d i u m 101 harder and shows on
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a d i u m 103 Sloughy Not sloughy .
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R a d i u m 105 But 2 of 15 cases h
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R a d i u m 107 Sice (not of tumor,
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IUM 109 Time well Number of cases i
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R a d i u m 111 died of a secondary
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R a d i u m 113 epithelioma of the
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R a d i u m 115 This writer also fo
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R a d i u m 117 as held by many wri
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R a d i u m 119 of foods, particula
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R a d i u m 121 which, in the last
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R a d i u m 123 "It has long been r
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R a d i u m 125 OBITUARY JAMES C. G
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