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182 Radium
Case I. Carcinoma involving the inner two-thirds of the lower eyelid. Duration 2 years. Treated by family physician
who made applications of some caustic solution.
This case received 500 milligram hours, applied to the surface of the growth in standard silver lubt>s (O.S millimeters
thick) covered with 1.0 millimeter of rubber.
The picture on ihe right: Showing complete retrogression of ihe tumor with only a slight scar which was soft and
pliable.
the above three factors, and he has arbitrarily established the standard
of four grades, depending upon the degree of differentiation of the
malignant cells, the number of mitoses seen, and the presence of atypical
chromatin masses. It is singularly true, then, that the more malignant
the growth according to McCarty's classification, the greater is its radiosensibility.
4. It is common knowledge that the endothelial lining of blood
and lymph vessels is very radio-sensitive, and that tumors having an
abundance of thin-walled, delicate capillaries react much more quickly
and favorably to radiation than corresponding tumors having a scanty
blood supply.
Ca&C 2. Carcinoma Involving the inner can thus of the left eye and the medial three-fourths of the ciliary margin of the
upper lid. It was first noted four years previously but had never been treated.
This growth received a total of 900 milligram hours applied on the surface. The radium waa contained Id 25 milligram
silver tubes0."> millimeters thick corcred with 1.0 millimeter of rubber.
Too picture on ihe right: Results of treatment, remaining clinically cured after t«« years. Showing absence of scar
formation or deformity. 5. Tumors having small amounts of intercellular connective tissue
react much more quickly and favorably to radiation than new growths
with a well formed supportive structure.
6. Secreting cells are in general much more radio-sensitive than
non-secreting cells, particularly if such cells produce crystalloid or crystallizable
material containing inorganic salts.
The presence or absence of any one of these characteristics to a
marked degree enables one to predict that the growth will or will not
react favorably to radiation properly applied.
The radio-susceptibility of cells does not in any way depend upon
the anatomical location, but depends entirely upon the histological picture
presented. For example, a lymphoid hyperplasia which is made
up of hyperchromatic undifferentiated cells is almost as vulnerable to
radiation as sex cells and will undergo retrogression with mild radiation