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80 R a d i u m (6) The greatly lessened discomfort to the patient during the radium treatments. (
R a d i u m 3i (.uisez. etc.). The latter recently reported several cases in which apparent cure has lasted nearly three years, where radiferous needles have been placed in and about the esophagus lesion under the direct control furnished by esopbagoscopy. In the exi>erience of the writer and his colleague there are many objections to esophagoscopv in these patients, who are weakened, old. and often in such a state of distress thai •-•sophagoscopy cannot be tolerated. Kven when accomplished, the implantation of needles is thoroughly done only around the upper jiole of :hc stricture, and there is the ever present danger of perforation, either immediately or after a few days. One case has been reported where death occurred from a small perforation into the aorta. In the employment of this technique "seeds" of radium emanation are preferable to any other form of radium applicator. 1 his method has the obviously great advantage of permitting accurate vision of the lesion and the progress of the treatment. Undoubtedly the method will appeal to the men who have had special training vt esophagoscopv. Purely Roentgen Method L'ndcr modern roentgenotherapeutic voltage, long focus-skin distance, large fieldsand heavy filtration,the administration of a highly efficient dosage of roentgen rays to the neighborhood of the esophageal lesion is feasible. The writer employs four fields,as a rule centering the radiation as nearly as possible u]khi the carefully mapped out objective. The dosage upon the skin is variable, the intention being to deliver to the lesion considerably more than a full erythema dose (120- 130 per cent E. S. D.). Our effort has been to deliver this tlose within about four days* time; but the observation of Kegaud and his colleagues give good ground for the belief that the same dose given in from ten 'o twelve days' time is more efficient, while being much less distressing to the already weakened, undernourished patient. Surely the roentgen method has the advantage of avoiding all intraesophageal manipulation. This, according to Simone Labord. is a reason for preferring the roentgen method to the exclusion of intraesophageal radium, for fear that radium treatment of esophageal cancer sometimes actually shortens the patient's existence. Combination Roentgen ami Radii'm Method A combination of the external application of roentgen radiation with the intraesophageal application of radium appears to the writer to be the ideal method. This belief is borne out by our clinical results which show greatest prolongation of life, although our results are no better than those reported by Mills a year ago. We have performed gastrostomy on three-quarters of our patients, and have given them by ibis means alone a marked degree of palliation. Comment In our work we prefer the method of gastrostomy under local anesthetic, followed in ten days by the placing of the thread, and three or four days later by the firstapplication of radium. A series of roentgen applications through four fields is then given, ifit has not already preceded the operation. On about the twentieth and twenty-fifth days further radium is applied, and a program of watchful waiting instituted. In the preparation of the radium applicator, whether for use by the sound or by the thread and gastrostomy method,it is our custom to use two.
Page 2: PRESENTED BY PUBLISHER
Page 6 and 7: CONTENTS OF VOLUME THREE. NEW SERIE
Page 8 and 9: F. W. Aston, D.Sc, F.R.S. Atoms and
Page 10 and 11: 2 Radium P. M. the apparatus is app
Page 12 and 13: Radium value of the metal container
Page 14 and 15: Radium Table I—Continued Classifi
Page 16 and 17: 8 RADIUM The affections of the thyr
Page 18 and 19: 10 R a d i u m The treatment should
Page 20 and 21: 12 Rapitjm ooo per cubic millimetre
Page 22 and 23: 14 Radium tines of tubercle bacilli
Page 24 and 25: 16 R A D I U M 4. Lymphatic Leukaem
Page 26 and 27: 18 RADIUM than in anv other organs
Page 28 and 29: 20 R a d i u m In a previous paper
Page 30 and 31: 99 Radium 2 mm. thick; the whole ap
Page 32 and 33: 2-1 Radium inum tubes in use. These
Page 34 and 35: 26 R a d i u m 5-gr. capsule and sw
Page 36 and 37: 28 R A D I U M 1 tared, as in the f
Page 40 and 41: 32 R a d i u m and at times three,
Page 42 and 43: 04 R a d i u m capsule is placed un
Page 44 and 45: 36 R a d i u m 1 have observed one
Page 46 and 47: 38 R A D I U M Frequency and Distri
Page 48 and 49: 10 R a d i u m holder with comparat
Page 50 and 51: 42 HADITJ M gestion of the eve whic
Page 52 and 53: 44 R a d i u m The low polymorphonu
Page 54 and 55: 46 Radium examined, it is believed
Page 56 and 57: 48 I^ADITJM Positive results of exp
Page 58 and 59: 50 R a d i u m 1 Is e III , -m If "
Page 60 and 61: »2 R a d i u m The summary of phys
Page 63 and 64: Radium 55
Page 65 and 66: R a d i u m 57 s V. — •7 CO N
Page 67 and 68: R a d i u m 59 Measuring radium by
Page 69 and 70: R a d i u m 6i Bibliography I. Gudz
Page 71 and 72: R a d i u m 68 Ited cells, SUBJECT
Page 73 and 74: R a d i u m TECHNIQUE OF RADIUM TRE
Page 75 and 76: R a d i u m B7 INDEX OF ARTICLES RE
Page 77 and 78: R a d i u m 69 Bower, J. O. and Cla
Page 79 and 80: R a d i u m 71 —Treatment of mali
Page 81 and 82: R a d i u m 73 —Carcinoma of oeso
Page 83 and 84: R a d i u m 75 —Uses of radium in
Page 85 and 86: R a d i u m 77 Kimbrough. J. B. and
Page 87 and 88: R a d i u m 7^ Lymph Nodes—Histol
Page 89 and 90:
R a d i u m si Nicolich—Carcinoma
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R a d i u m 83 Radium— —Large d
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a d i u m 85 -Physical conditions o
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R a d i u m ST Arch. f. Gynak. 118:
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R a d i u m 89 Scholten, G. C. J.
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R a d i u m 91 (A. J. Larkin) Am. J
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R a d i u m 93 —Xecessity for com
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RADIUM 95 Wallerstein, E. U.—X-ra
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A QUARTERLY JOURNAL DEVOTED TO THE
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R a d i u m 99 casionally a carcino
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R a d i u m 101 would be detected w
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R a d i u m 103 cially likely if th
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R A D I U M 105 radium irradiations
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R a d i u m 107 that in nearly ever
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R a d i u m 109 liver and lung meta
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Radium in Appleton Co., 1922. (2) P
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R a d i u m 113 BLOCKING LYMPHATICS
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R a d i u m 115 removed, and the ra
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R a d i u m in PATHOLOGY Pathologic
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4. Cauhape: Thesis. Paris. 1911. R
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R a d i u m 121 is necessary by thi
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Radium 123 is injected into the tis
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R a d i u m 125 (3) Polonaise Numbe
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R a d i u m 127 modern laboratories
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R a d i u m 129 NINTH ANNUAL MEETIN
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R a d i u m 131 Several distinguish
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R a d i u m 133 which X-rays or rad
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R A D I U M 135 In the autobiograph
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R A D I U M 137 of radical operatio
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R a d i u m 139 reports 26 cases, 8
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R a d i u m 141 George W. Crile, M.
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R a d i u m 143 "In carcinoma of th
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R a d i u m 145 " 1 he principal ob
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IUM 147 have found no means of obvi
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R a d i u m 149 and six hours. Now
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R a d i u m 151 thoroughly transfix
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R a d i u m 153 weakness, palpitati
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R a d i u m 155 had all been benefi
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R a d i u m i57 tation of the kidne
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Radium 159 Can walk only with a can
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R a d i u m 163 in operative clinic
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a d i u m 165 In Table II we have d
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Hajmu.m 167 tery was used in combin
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R a d i u m 169 TABLE IX.—RESULTS
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R a d i u m m Radium alone Class i.
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R a d i u m 173 and papillary carci
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R a d i u m 175 It grows rapidly, i
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R a d i u m 177 emanation tubes. Th
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R a d i u m 179 never at any time f
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R a d i u m 181 THE TREATMENT OF MA
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R a d i u m 183 Cast 3. Carcinoma a
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R a d i u m 185 Chm 7. Showing cond
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R a d i u m 187 courting disaster b
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R a d i u m 189 radium in the treat
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R a d i u m 191 Histologic changes
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R a d i u m 193 about their involut
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R a d i u m 195 due to x-ray, sunli
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R a d i u m 197 zation of a partial
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R a d i u m 199 to report his cases
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201 very often will result in a dec
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R a d i u m 203 the cautious use of
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IUM 205 On Jan. 14th. which was a v
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CONCLUSIONS 207 That in some cases
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R a d i u m 209 (b) The fluorescent
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R a d i u m •, 211 patient. The p
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R a d i u m 213 radiological depart
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R a d i u m 215 fortunately, the im
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R a d i u m 217 know whether such c
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R a d i u m 219 eight months had el
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R a d i u m 221 "The selective and
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R a d i u m 223 of a simple unitary
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R a d i u m 227 in their beta ray a
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R a d i u m 229 or the gradation of
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R a d i u m 231 be left in malignan
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R a d i u m 233 during repeated cau
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R a d i u m 235 3. The presence of
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R a d i u m 237 situated at the lim
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R a d i u m 239 REFERENCES 1. Wickh
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Rajpium 241 the test of five years,
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R a d i u m 243 comparative statist
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R a d i u m 245 end results of 201
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R a d i u m 247 Operation Hysterect
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R a d i u m 'IV.) and five years, a
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R a d i u m 251 or effect upon, the
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R a d i u m 253 2. Early Cases.—T
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R a d i u m 255 groups: the superfi
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R a d i u m 257 "I am becoming more
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R a d i u m 259 ment of 'Radiumhemm
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R a d i u m 261 unusual symptoms an
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R a d i u m 263 dition continued sa
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R a d i u m 265 died from hemorrhag
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R a d i u m 267 equals 132 millicur
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R a d i u m 269 "The data in the li
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R a d i u m 271 animals a diminutio
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R a d i u m 273 rays as contrasted
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R a d i u m 275 depression than a d
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R a d i u m 277 repeated operations
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R a d i u m 279 tonsil completely,
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Radium 281 Ihe tonsil is dangerous
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R a d i u m 283 WILLIAM H. B. AIKIN
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DEVOTED TO THE CHEMISTRY, PHYSICS A
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PUBLISHED SEMI-ANNUALLY AND DEVOTED
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R a d i u m 3 ORAL CANCER The next
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lymph nodes in even case, but when
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adiation up to 2400 milligram hours
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R a d i u m o radium to relieve pat
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R a d i u m 11 Uterine Fibroids The
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R a d i u m i3 by some operators. X
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R a d i u m 15 from the operation h
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R a d i u m n tions, the distance s
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R a d i u m 19 APPENDIX RADIUM AND
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Radium 21 BASIC AND CONTBIBUTING FA
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RA.PIUM 23 X-RAY AND RADIUM THERAPY
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R a d i u m 25 Since, by the impact
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R a d i u m 27 duccd which were cov
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R a d i u m 29 In other cases the g
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R a d i u m 31 The recital of this
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R a d i u m 33 index of articles re
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R a d i u m 35 Block, F. B., and Cl
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R a d i u m ?,- J. R. Ranson) Color
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R a d i u m :;:» —Epithelioma of
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R a d i u m 4I Forsdike. S.-Cancer
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R a d i u m 43 Hot Springs, Arkansa
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R a d i u m 45 Lee. B. J., and Here
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R a d i u m 47 Mineral Waters, exam
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R a d i u m 49 —Treatment of inop
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R a d i u m 51 - Metabolic changes
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R a d i u m 58 Radium, emanation—
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R a d i u m .>.) —Physiological a
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R a d i u m 57 —Experimental rese
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R a d i u m 59 Spleen, physiology
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R a d i u m 6l —Animal tumor cell
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R a d i u m es —Treatment of uter
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PUBLISHED SEMI-ANNUALLY AND DEVOTED
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R a d i u m e? CONTRAINDICATIONS TO
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R a d i u m 69 in addition to the i
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Radium 71 the most common, in the o
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R a d i u m ?:; nexae is a positive
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R a d i u m 76 essential to success
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R a d i u m 77 Our technique is to
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carcinoma of the CERVIX R a d i u m
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R a d i u m 81 a bleeding, cauliflo
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R a d i u m HS Fibrinous patch on e
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R a d i u m sr, mal 7 days later. A
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R a d i u m ST idly develops and me
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R a d i u m 89 2. Cervical cancer o
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R a d i u m 91 irradiation treatmen
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R a d i u m 93 by a study of curett
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R a d i u m 96 parenchyma eventuall
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R a d i u m 97 ihe lowest (2) was t
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R a d i u m 99 3. The treatment int
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R a d i u m 101 harder and shows on
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a d i u m 103 Sloughy Not sloughy .
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R a d i u m 105 But 2 of 15 cases h
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R a d i u m 107 Sice (not of tumor,
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IUM 109 Time well Number of cases i
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R a d i u m 111 died of a secondary
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R a d i u m 113 epithelioma of the
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R a d i u m 115 This writer also fo
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R a d i u m 117 as held by many wri
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R a d i u m 119 of foods, particula
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R a d i u m 121 which, in the last
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R a d i u m 123 "It has long been r
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R a d i u m 125 OBITUARY JAMES C. G
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