Cyanoguanidine CAS NÂ°: 461-58-5

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OECD SIDS CYANOGUANIDINE 4. ECOTOXICITY ID: 461-58-5 DATE: 25.02.2004 (93.9) (103) (102) ------------------------- -------------------- ------------------ --------------- 50.0 48.9 51.3 49.6 (97.8) (103) (99.2) ------------------------- -------------------- ------------------ --------------- 100 93.8 102 100 (938) (102) (100) ------------------------- -------------------- ------------------ --------------- - Effect data (Mortality): ------------------ ------------------------------------------------------------------------------- Nominal Cumulative Mortality (% Mortality) concentration 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14-day [mg/L] ------------------ ------------------------------------------------------------------------------- Control 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 6.25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 12.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 25.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 50.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0 0 0 0 0 0 0 0 0 0 0 0 0 0 0) ------------------ ------------------------------------------------------------------------------- 7 d-LC50 > 100 mg/L 14 d-LC50 > 100 mg/L 14 day lowest test substance concentration resulting in 100% mortality = 100 mg/L - Other effects: No toxicological symptom was observed during test period. 14 day the lowest effective concentration = 100 mg/L RESULTS: CONTROL - Nature of adverse effects: none RESULTS: TEST WITH REFERENCE SUBSTANCE - Reference substance: CuSO4-5H2O- Results: 96 hr LC50 = 0.930 mg/L Test condition : TEST ORGANISMS- Strain: Oryzias latipes - Supplier: NAKAJIMA FISH HATCERY (Japan) - Size/weight: 2.0 cm (1.9 - 2.1 cm), n = 10 / 0.12 g (0.10 - 0.15 g), n = 10 - Feeding: "TETRAMIN" - Pretreatment: acclimated for 7 day before testing, mortality was less than 5%. Not fed for 24 hr before the test started. - Feeding during test: 2% of fish weight daily. STOCK AND TEST SOLUTION AND THEIR PREPARATION - Vehicle, solvent: No solvent was used. STABILITY OF THE TEST CHEMICAL SOLUTIONS: Cyanoguanidine was stable, and not hydrolyzed after 14 days. REFERENCE SUBSTANCE: CuSO4-5H2O DILUTION WATER - Source: dechlorinated tap water - Aeration: aerated sufficiently. 42 UNEP PUBLICATIONS
OECD SIDS CYANOGUANIDINE 4. ECOTOXICITY ID: 461-58-5 DATE: 25.02.2004 - Alkalinity: 29.0 mg/L - Hardness: 40.5 mg/L as CaCO3 - Residual chlorine: less than 0.02 mg/L as Cl - pH: 7.6 TEST SYSTEM - Concentrations: 6.25, 12.5, 25.0, 50.0, 100 mg/L - Renewal of test solution: flow through 25.0 mL/min - Exposure vessel type: size; 1.8 L test solution in a 3 L glass beaker - Number of replicates, fish per replicate: 1, 10 - Test temperature: 24 plus or minus 1 degree C - Dissolved oxygen: 7.5 - 8.2 mg/L - pH: 7.1 - 7.7 - Intensity of irradiation: room light - Photoperiod: 16 - 8hr light-dark cycle DURATION OF THE TEST: 14 day TEST PARAMETER: mortality, abnormal behavior, abnormal respiration SAMPLING: immediately after the preparation on 0, 7, 14 day MONITORING OF TEST SUBSTANCE CONCENTRATION: analyzed by HPLC at the start (0-day), middle (7-day) and the end (14-day) of test period Test substance : SOURCE: Wako Pure Chemical Industries, LTD (Japan) PURITY: 99.2% IMPURITY/ADDITIVE/ETC.: not described ANY OTHER INFORMATION: Lot No.WTM0467 Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 31.07.2003 (20) Type : Species : Oryzias latipes (Fish, fresh water) Exposure period : Unit : Analytical monitoring : Method : other Year : GLP : No Test substance : Result : 24hr-TLM> 2300 ppm 48hr-TLM> 2300 ppm Test condition : Dose: 700, 1700, 2319 ppm Period: 24, 48 hr n = 10 Reliability : (3) invalid 26.06.2003 (35) Type : Species : Rutilus rutilus (Fish, fresh water) Exposure period : Unit : mg/l Analytical monitoring : Schwellenwert der : m = 9000 Giftwirkung (Threshold value of the poison effect) Method : Year : GLP : No Test substance : Reliability : (4) not assignable 26.06.2003 (43) UNEP PUBLICATIONS 43
Page 1 and 2: OECD SIDS CYANOGUANIDINE FOREWORD I
Page 3 and 4: OECD SIDS CYANOGUANIDINE SIDS INITI
Page 5 and 6: OECD SIDS CYANOGUANIDINE SIDS Initi
Page 7 and 8: OECD SIDS CYANOGUANIDINE 2.2.4 Tran
Page 9 and 10: OECD SIDS CYANOGUANIDINE Eye Irrita
Page 11 and 12: OECD SIDS CYANOGUANIDINE 3.1.6 Muta
Page 13 and 14: OECD SIDS CYANOGUANIDINE This subst
Page 15 and 16: OECD SIDS CYANOGUANIDINE [Zacherl e
Page 17 and 18: OECD SIDS CYANOGUANIDINE Matsushima
Page 19 and 20: OECD SIDS CYANOGUANIDINE 1. GENERAL
Page 27 and 28: OECD SIDS CYANOGUANIDINE 2. PHYSICO
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Page 31 and 32: OECD SIDS CYANOGUANIDINE 3. ENVIRON
Page 41: OECD SIDS CYANOGUANIDINE 4. ECOTOXI
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Page 53 and 54: OECD SIDS CYANOGUANIDINE 5. TOXICIT
Page 73 and 74: OECD SIDS CYANOGUANIDINE 6. REFEREN
Page 75: OECD SIDS CYANOGUANIDINE 6. REFEREN

Cyanoguanidine CAS NÂ°: 461-58-5

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