Cyanoguanidine CAS N°: 461-58-5

OECD SIDS
CYANOGUANIDINE
5. TOXICITY ID: 461-58-5
DATE: 25.02.2004
gain was more marked in both sexes of the 10 % group and in females of
the 5 % group. as compared with the control group. Mean food intake in
male of the group treated with 5 % or 10 % and in females of the 10 %
group significantly higher than in the control group. Serum biochemical
investigation revealed a higher level of serum BUN in both sexes of the 10
% group. On histopathological examination, toxic changes characterized by
the occurrence of intranuclear eosinophilic inclusion bodies in the proximal
tubular epithelium of the kidney were observed in both sexes of the 10 %
group. Similar inclusion bodies were also seen in 2 out of 10 males of 5 %
group.
NOAEL is 2.5 %/day for both sexes.
Test condition : Rat: SPF, Charles River Japan
10 animal/group/sex (total 100 animals)
Converted value:
Male;
1.25%: 571 mg/kg/day
2.5%: 1230 mg/kg/day
5%: 2602 mg/kg/day
10%: 5782 mg/kg/day
Female;
1.25%: 707 mg/kg/day
2.5%: 1500 mg/kg/day
5%: 2978 mg/kg/day
10%: 6822 mg/kg/day
Test substance : Sanwa Chemical (purity = 99.9 %)
Reliability : (4) not assignable
26.11.2003 (37)
Species : guinea pig
Sex :
Strain :
Route of admin. : inhalation
Exposure period :
Frequency of
: 4 weeks
treatment
Post obs. period :
Doses :
Control group :
Method :
Year :
GLP : no data
Test substance :
Result : TCLo = 2400 ug/m3
Reliability : (3) invalid
26.11.2003 (57)
Species : rat
Sex :
Strain :
Route of admin. : inhalation
Exposure period : 4 weeks
Frequency of
:
treatment
Post obs. period :
Doses :
Control group :
Method :
Year :
GLP : no data
Test substance :
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