Cyanoguanidine CAS N°: 461-58-5

OECD SIDS
CYANOGUANIDINE
5. TOXICITY ID: 461-58-5
DATE: 25.02.2004
Remark : The result essentially is not influence of dicyandiamide.
Result : The results of the tests conducted on the test material in the absence or
presence of a metabolic activation system were positive with the strains
TA100 and TA1535.
The test material (dicyandiamide included) exhibited genetic activity with
the strains TA100 and TA1535 in the nonactivation and activation assays
conducted in this evaluation and was considered mutagenic under these
conditions according to their evaluation criteria.
Test condition : Metabolic activation system: 10% S-9 mix from male Sprague-Dawley
induced Aroclor 1254
Solvent: DMSO
Negative control: DMSO
Positive Control: -S9; Sodium azide, 2-Nitrofluorene, 9-Aminoacridine, +S9;
2-anthramine
Test substance : Dicyandiamide was one component of a rigidite.
The rigidite was used in this test.
Reliability : (4) not assignable
26.11.2003 (30)
Type : Ames test
System of testing : Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538
Concentration : 44-9300 ug/plate
Cycotoxic conc. :
Metabolic activation : with and without
Result : positive
Method : other
Year : 1985
GLP : no data
Test substance : other TS
Remark : The result essentially is not influence of dicyandiamide.
Result : Resins tested were weakly mutagenic in strains TA1535 and TA100 in the
presence and absence of metabolic activation. The presence of metabolic
activation significantly increased the mutagenicity of resins in strain
TA1535. However, metabolic activation did not appreciably alter the
mutagenicity in strain TA100. Resins were non-mutagenic in strains
TA1537, TA1538, and TA98.
Test substance : Dicyandiamide was one component of resins as 0.8%.
The resin was used in this test.
Unknown the influence of cyanoguanidine to the results
Reliability : (4) not assignable
26.11.2003 (15)
Type : Ames test
System of testing : Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538
Concentration : Without metabolic activation: 0.01, 0.05, 0.1, 0.5, 1.0, 2.5, 5.0 mg/plate,
With metabolic activation (mouse S-9 mix): 0.1, 0.5, 1.0, 2.5, 5.0 mg/plate,
(maize fraction S-14): 0.1, 1.0, 5.0, 10.0 mg/plate
Cycotoxic conc. : No cytotoxicity was observed to 1.0 mg/mL.
Metabolic activation : with and without
Result : negative
Method : other
Year :
GLP : no
Test substance : other TS
Result : This substance reduced the numbers of bacterial colonies in plates with 10,
5 or 2.5 mg/plate, respectively. It did not exert mutagenic effects on tester
strains incubated was observed in strain TA1535 when tested with 0.1, 0.5
and 1.0 mg per plate.
Test condition : Metabolic activation system: S-9 mix from mouse liver homogenate
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