Cyanoguanidine CAS N°: 461-58-5

OECD SIDS
CYANOGUANIDINE
5. TOXICITY ID: 461-58-5
DATE: 25.02.2004
- Vehicle: 3% gum arabic solution
- Concentration in vehicle: 0, 8, 40, 200 mg/mL
- Doses: 0, 40, 200, 1000 mg/kg/day
- Volume: 5 mL/kg
Clinical Observation and Frequency:
- Clinical signs: daily
- Mortality: daily
- Body weight and Food consumption: males and females; 0, 3, 7, 14 day
from dose start, after then, one day per week. At mated female, 0, 7, 14,
20 day from pregnancy and 0, 4 day from lactation.
Test substance : Purity: 99.8%,
lot No. :L-2271,
NIPPON CARBIDE INDUSTRIES CO.,INC.
Conclusion : The NOAEL for repeat dose toxicity is considered to be 1000 mg/kg/day for
both sexes.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
26.11.2003 (39)
Species : rat
Sex :
Strain : Fischer 344/DuCrj
Route of admin. : oral feed
Exposure period : 14 days
Frequency of
: ad libitum
treatment
Post obs. period : no
Doses : 0, 5, 10% mixed with CRF-1 feed
Control group : yes
NOAEL : = 10 %
Method : other
Year :
GLP : no data
Test substance : other TS
Result : No death was observed during test period.
Decrease in body weight were observed with dose response, although
increase in food consumption.
No toxicity was observed to 10% group.
Test condition : Rat: SPF, Charles River Japan
3 animal/group, female
Not converted to mg/kg/day
Test substance : Sanwa Chemical (purity = 99.9 %)
Reliability : (4) not assignable
26.11.2003 (37)
Species : rat
Sex : male/female
Strain : Fischer 344/DuCrj
Route of admin. : oral feed
Exposure period : 13 weeks
Frequency of
: ad libitum
treatment
Post obs. period : no
Doses : 0, 1.25, 2.5, 5, 10% mixed with CRF-1 feed
Control group : yes
NOAEL : = 2.5 %
Method : other
Year :
GLP : no data
Test substance : other TS
Result : No animals died during the administration period. Inhibition of body weight
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