Cyanoguanidine CAS N°: 461-58-5
Cyanoguanidine CAS N°: 461-58-5
Cyanoguanidine CAS N°: 461-58-5
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OECD SIDS<br />
CYANOGUANIDINE<br />
5. TOXICITY ID: <strong>461</strong>-<strong>58</strong>-5<br />
DATE: 25.02.2004<br />
Method : other<br />
Year : 1985<br />
GLP : yes<br />
Test substance : other TS<br />
Remark : The result essentially is not influence of dicyandiamide.<br />
Result : Without metabolic activation: Statistically significant increases in sister<br />
exchanges were observed at 333 nL/mL and 1.0 uL/mL with a dose<br />
response established observed the test article is considered positive in the<br />
sister chromatid exchange assay under of non-metabolic activation.<br />
With metabolic activation: There were statistically significant increases in<br />
sister exchanges were observed at 3.3 uL/mL and 10.0 uL/mL with a dose<br />
response established. The test article is considered positive under the<br />
condition of metabolic activation in the sister chromatid exchange assay.<br />
Test condition : Metabolic activation system: S-9 from male Sprague-Dawley induced<br />
Aroclor 1254, S-9 15 uL/mL of S-9 mix<br />
Controls:<br />
Negative control; McCoy's 5a medium<br />
Solvent control; DMSO<br />
Positive control; Mitomycin C<br />
Test substance : Dicyandiamide was one component of a rigidite.<br />
The rigidite was used in this test.<br />
Reliability : (4) not assignable<br />
26.11.2003 (30)<br />
5.6 GENETIC TOXICITY ‘IN VIVO‘<br />
5.7 CARCINOGENITY<br />
Species : rat<br />
Sex : male/female<br />
Strain : Fischer 344<br />
Route of admin. : oral feed<br />
Exposure period : 104 weeks<br />
Frequency of<br />
: ad lib.<br />
treatment<br />
Post. obs. period : 9 weeks<br />
Doses : 2.5, 5.0 % (converted values: male; equivalent to 837.2 and 19<strong>58</strong>.6<br />
mg/kg/day, female; equivalent to 1001.3 and 2169.2 mg/kg/day)<br />
Result : negative<br />
Control group : yes<br />
Method : other<br />
Year :<br />
GLP : no data<br />
Test substance : other TS<br />
Result : -Non-neoplastic lesions<br />
-------------------------------------------------------------------------------------------<br />
No. of rats with lesions<br />
Male Female<br />
Dose (%) 0 2.5 5 0 2.5 5<br />
-------------------------------------------------------------------------------------------<br />
Effective No. of rats 49 50 49 49 50 50<br />
------------------------------------------------------------------------------------------<br />
Liver<br />
Bile duct hyperplasia 44 46 47 10 15 23**<br />
Hepatocellular altered foci 25 31 33 32 38 40<br />
-------------------------------------------------------------------------------------------<br />
Kidney<br />
UNEP PUBLICATIONS 65
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