DRUG-INDUCED LEUKOPENIA
DRUG-INDUCED LEUKOPENIA
DRUG-INDUCED LEUKOPENIA
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INCIDENCES<br />
(<strong>LEUKOPENIA</strong>/NEUTROPENIA)<br />
Drugs<br />
Micromedex 12 Lexi-comp 13<br />
Incidence Onset Recovery Incidence Onset Recovery<br />
Linezolid<br />
Vancomycin<br />
Rifampicin<br />
1.1% (adult) >14 days<br />
rare<br />
>7 days<br />
or total<br />
dose<br />
>25g<br />
Upon<br />
Discont’<br />
Promptly<br />
reversed<br />
when<br />
discont’<br />
N/A N/A N/A<br />
1%-10% >14 day N/A<br />
1%-10%<br />
Not defined,<br />
Dose related<br />
>7 days or<br />
total dose<br />
>25g<br />
N/A<br />
Promptly<br />
reversed<br />
when<br />
discont’<br />
N/A<br />
Azathioprine<br />
Dose<br />
related<br />
Delay<br />
reversed<br />
discont’ or<br />
reduce<br />
dose<br />
Not defined,<br />
Dose related<br />
Delay<br />
N/A<br />
12) Micromedex Healthcare Series. 150 ed. US: Thomsom Reuther; 2011.<br />
13) Lacy CF, Armstrong LL, Goldman MP, Lance LL. Drug information handbook with international trade names index. 19 th ed. Ohio: Lexi-Comp Inc.; 2010.
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