year-2-study-guide-2.. - School of Medicine - Trinity College Dublin

Medical proteomics (2 lectures)
Lecturer: Dr. Henry Windle
Summary of the topics covered:
Introduction to medical proteomics. Proteomics in biomarker discovery. Applications
of proteomics for improved medical diagnostics and drug development. Protein chips
and arrays. Human proteome organisation.
Molecular basis of psychiatric disorders (2 lectures)
Lecturer: Dr. Derek Morris, Dr. Richard Anney
Summary of the topics covered:
Psychiatric diseases as complex genetic disorders. Mutations in DNA and molecular
genetic of psychiatric disorders. Endophenotypes in the analysis of psychiatric
diseases. Linkage and association studies.
Molecular mechanisms in aetiology of ADHD. Applications of molecular genetics in
diagnostics of psychiatric diseases. Mouse models of ADHD. Dopaminergic
hypothesis in ADHD. Treatment approaches and their link to research in ADHD.
Indicative Resources
The cell: a molecular approach (Geoffrey M. Cooper)
Developmental Biology (Gilbert S., 7th Edition, SinauerPress).
Molecular cell biology (Harvey Lodish et al.)
Molecular biology of the cell (Bruce Alberts et al.).
Encyclopedia of molecular cell biology and molecular medicine (Robert A. Meyers)
Molecular Medicine (R.J.Trent)
Essentials of Human Embryology (Larsen)
Introduction to Molecular Medicine (Ross, Dennis W.)
An Introduction to Molecular Medicine and Gene Therapy (Thomas F. Kresina)
Learning Outcomes
The overall objective of this module is to empower the students with the knowledge
of the essential aspects of molecular mechanisms of disease development
accumulated over the recent years and to enable the medics to apply this information
in clinical environment for improved diagnostic and treatment of the patients.
On successful completion of this module, the students will be able to:
• Identify the molecular mechanisms involved in human development,
developmental abnormalities, tissue damage, regeneration and recognise stem
cell applications in this context;
• Describe the fundamental molecular mechanisms of cell communications and key
intracellular processes underlying inflammatory diseases and human host
defence responses;
• Explain the genetic and environmental factors involved in the development of
cancer and haematological malignancies and understand the key stages of
cancer development and progression;
• Explain how structural and functional analysis of molecules can be applied to the
generation of novel drugs and design of new therapies, including gene delivery
and gene therapy;
• Explain the molecular processes underlying common psychiatric disorders;
• Discuss how contemporary molecular medicine technologies can be applied for
the development of new diagnostic methods and molecular approaches for
therapeutic intervention
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