year-2-study-guide-2.. - School of Medicine - Trinity College Dublin

nucleus, putamen, lentiform nucleus, globus pallidus, substantia nigra, subthalamic nucleus
and the nucleus accumbens; Connections and basic circuits; Hypokinesia, hyperkinesia,
tremor and rigidity; Information from clinical disorders such as Parkinson's Disease,
Huntington's chorea and hemiballismus.
(Physiology) Synaptic transmission and neurotransmitter receptors 3
Synaptic transmission and neurotransmitter receptors continued.
(Biochemistry) Aminergic Transmission 2. Dopamine neurotransmission. Consequences of
its disruption (MPTP and Parkinson's disease). Consequences of enzyme inhibition in
depression, mania, Parkinson's disease. The role of catechol-O-methyltransferase and
possible consequences of its inhibition.
(Psychiatry) Cognitive development II
Emotional intelligence, a popular concept in recent years; the evidence to support the
concept. The development of social cognition is discussed, for example empathy, self-control
etc., and how these are related to the concept of emotional intelligence.
(Psychiatry) The Psychology of Memory
Normal memory and forgetting, the effects of stress and psychological state on memory.
False memories.
(Biochemistry) The amino-acid transmitters (glutamate, GABA and glycine).
Glutamate and GABA neurotransmission. Criteria and experimental investigation of putative
neurotransmitters. Epilepsy and anti-convulsants. Similarities and differences between
different systems (amines, acetylcholine, amino acids and peptides). Uptake mechanisms,
enzymic inactivation (intracellular and extracellular). Reversal of uptake in ischaemia.
(Anatomy) Ascending pathways
Spinal ganglia; Modalities of sensation and their segregation; Posterior grey horn; Laminae
of Rexed; Clarke's thoracic nucleus; Spinothalamic pathway; Posterior column/ medial
lemniscal pathway; Spinoreticular tract; Spino-olivary tract; Spinotectal tract; Posterior
spinocerebellar and cuneocerebellar tracts; Anterior spinocerebellar and rostral
spinocerebellar tracts; Dissociated anaesthesia; Brown-Séquard syndrome.
(Physiology) (Physiology) Synaptic transmission and neurotransmitter receptors 4
Synaptic transmission and neurotransmitter receptors continued.
WEEK 3
(Pharmacology) Local Anaesthetics
General properties of local anaesthetics, their pharmacokinetics, pharmacodynamics and
actions on various body systems.
Factors affecting differential nerve sensitivity including use-dependent block. Side effects of
local anaesthetics and those associated with accompanying use of vasoconstrictors. Amides
and ester classification.
Methods / routes of administration.
(Biochemistry) Some other transmitters
Hypoxia and ischemia responses - excitotoxic and re-perfusion damage. Formation,
functions and possible toxicity of NO. Possible functions of D-serine. CO. Other possible
retrograde messengers.
(Anatomy) Descending pathways
Anatomy of anterior grey horn; Tonic and phasic alpha-motor neurons; Renshaw cells; Spinal
reflexes; Corticospinal tract; reticulospinal, vestibulospinal, tectospinal and olivospinal tracts;
Raphespinal tract, aminergic pathways and sentral autonomic pathway; Upper and lower
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