year-2-study-guide-2.. - School of Medicine - Trinity College Dublin

Course Content
LECTURES
WEEK 1
(Biochemistry) Cell-types in the brain and their functions.
Introduction. Glial cell diversity and specialisation. Neurone-glial cell interdependence.
Organelle transport (anterograde & retrograde). Neurotransmitter diversity & criteria.
(Anatomy) Introduction: CNS development
Ectodermal origin of the neural plate, neural folds and neural tube; Formation of brain and
spinal cord; Alar and basal plates; Motor and sensory neurons; Rhombencephalon
(myelencephalon and metencephalon), mesencephalon and prosencephalon (diencephalon
and telencephalon); Formation of the medulla, pons, midbrain, cerebellum, basal ganglia,
thalamus, hypothalamus, pituitary and the cerebral hemispheres; Development of the
ventricular system.
(Physiology) Ionic channels 1
-properties of ionic channels, especially Na, Ca K and Cl channels
-involvement of voltage gated channels in generation of action potential
(Anatomy) Cerebral hemispheres: topography
Meninges; Sulci; Gyri; Frontal, parietal, temporal, occipital and limbic lobes; Inferior aspect of
brain; Insula; Cortical areas (Brodmann); Primary motor cortex; Premotor cortex;
Supplementary motor area; Primary sensory cortex; Auditory cortex and language areas;
Visual cortex; Association cortex; Commisural, projection and association fibres; Structural
aspects; laminar organisation of the cerebral cortex; Isocortex and neocortex.
(Physiology) Ionic channels 2
Ionic channels continued.
(Biochemistry) Neuro-Techniques and Brain Metabolism. Methods for studying
neurotransmission. Synaptosomes, cultured cells and other model systems. Tracing and
identification of tracts. Composition, types, bioenergetics, storage and transport, exocitosis.
Synaptic vesicles (SSVs and LDCVs).
(Psychiatry) Brain and Mind- Would this lecture (given by Ian Robertson work as a nice
overview to the whole course? I could send him on details or a slide indicating the areas
represented on the course.
What we know about the interaction between brain processes and mental states. The
interactions between the physical and the mental and between biological and psychological.
(Psychiatry) Cognitive development I
Piaget’s theory as the main theory of cognitive development, how theories of development
might inform clinical work, Intelligence and its measurement, the concept of IQ and its
advantages and limitations.
(Biochemistry) Acetylcholine neurotransmission. NMJ. Docking proteins and evidence from
botilinus and tetanus toxins. Stimulation of release by chemical, neurotoxic, ionic and
electrical means. Mechanisms and control of release - the role of calcium ions and of
phosphorylation events.
(Anatomy) Ventricles and CSF
Lateral ventricle: Central part, with frontal, occipital and temporal horns; interventricular
foramen; relationship with caudate nucleus, septum pellucidum, corpus callosum, fornix,
thalamus, forceps major, calcar avis, amygdala, hippocampus and tela choroidea. Third
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