Clinical Approach to Medical Management of Type 2 Diabetes

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Antihyperglycemic Agents 1. Biguanides (Metformin) 2. Sulfonylurea 3. Meglitinides 4. Insulins 5. Thiazolidinediones (TZDs) 6. Dipeptidyl Peptidise-4 (DPP4) Inhibitors 7. Glucagon-Like Peptide 1 (GLP1) Analogues 8. Alpha-Glucosidase Inhibitors 9. Colesevelam 10. Bromocriptine 11. Amylin agonists
Type 2 DM Treatment – Practical Tips: • All oral agents require presence of functioning Beta-cells as they work by either increasing their function or enhancing insulin sensitivity • Higher baseline A1c levels predicts a greater drop in A1c • Shorter duration of diabetes predicts greater drop in A1c level
Page 1 and 2: Clinical Approach to Medical Manage
Page 3 and 4: Outline: 1. Glycemic Targets in Typ
Page 5 and 6: Glycemic Goals of Therapy in Outpat
Page 7 and 8: Adjusted Hazard Ratio for Clinical
Page 9 and 10: Benefit assessment of long-term blo
Page 11: Outline: 1. Glycemic Targets in Typ
Page 15 and 16: The Biguanides: Basic Characteristi
Page 17 and 18: 10-Year Follow-up of Intensive cont
Page 19 and 20: Metformin: Old Drug, New Targets Li
Page 21 and 22: Secretagogues: Sulfonylureas and th
Page 23 and 24: Secretagogues: Sulfonylureas and th
Page 25 and 26: Sulfonylurea Versus Newer Agents: G
Page 27 and 28: Basic Characteristics of Glitazones
Page 29 and 30: Pioglitazone • Is not associated
Page 31 and 32: The α-Glucosidase Inhibitors: Basi
Page 33 and 34: Types of Insulins • Basal insulin
Page 35 and 36: Prandial Versus Basal Insulin: The
Page 37 and 38: Insulin Initiation and Titration
Page 39 and 40: Colesevelam vs. Placebo in combinat
Page 41 and 42: Cycloset Safety Trial HR Bromocript
Page 43 and 44: • N=656 • DM2 for ~12 yrs • B
Page 45 and 46: So, we have 11 different classes of
Page 47 and 48: Comparative Effectiveness and Safet
Page 49 and 50: Pooled between-group differences in
Page 51 and 52: Effect of Antihyperglycemic Agents
Page 53 and 54: Yearly Cost for Different Antihyper
Page 55 and 56: 2012 Position Statement of the ADA
Page 57: Thank You !

Clinical Approach to Medical Management of Type 2 Diabetes

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