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Clinical Approach to Medical Management of Type 2 Diabetes

Clinical Approach to Medical Management of Type 2 Diabetes

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Treat <strong>to</strong> Target in <strong>Type</strong> 2 <strong>Diabetes</strong> Trial<br />

• 708 patients not controlled<br />

with MF or SU<br />

• Duration – 3 years<br />

• Baseline A1c 8.3%<br />

• Treatment groups:<br />

– Basal insulin QD/BID (detemir)<br />

– Prandial insulin TID (aspart)<br />

– Biphasic insulin BID/TID<br />

(NovologMix 70/30)<br />

A1c 6.9%<br />

Holman et al, NEJM, 2009

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