Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
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Effect <strong>of</strong> Antihyperglycemic Agents Added <strong>to</strong> Metformin<br />
and a Sulfonylurea on Glycemic Control and Weight<br />
Gain in <strong>Type</strong> 2<strong>Diabetes</strong>: A Network Meta-analysis<br />
• To evaluate the effect <strong>of</strong> the THIRD antihyperglycemic<br />
agents in the reduction <strong>of</strong> HbA1c level, change in body<br />
weight, and the frequency <strong>of</strong> severe hypoglycemic events<br />
• Meta-analysis <strong>of</strong> 18 trials, 4535 participants<br />
• Mean duration <strong>of</strong> follow-up 31 weeks (26 -52 weeks)<br />
• Duration <strong>of</strong> diabetes 7.5 – 13.1 years<br />
• Baseline A1c 7.5 – 10.6%<br />
Gross et al, Ann Intern Med, 2011
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